4-Chloro-3-fluoropyridine

Basic Information

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CAS Number

2546-56-7

Molecular Formula

C5H3ClFN

Molecular Weight

131.54 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Melting Point

-24°C

Boiling Point

139°C

Refractive Index

1.5010 to 1.5050

SMILES

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C1=CN=CC(=C1Cl)F

InChI

InChI=1S/C5H3ClFN/c6-4-1-2-8-3-5(4)7/h1-3H

InChIKey

BEQUUSCRAKEKQM-UHFFFAOYSA-N

LogP

1.8741

Topological Polar Surface Area

12.89 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Complexity

78.8

Safety Information

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GHS Hazard Pictograms

H226

H315

H319

H335

Hazard Statement

H226 Flammable liquid and vapor
Flammable liquids

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

FT-0634353
4-chloro-3-fluoro-pyridine
MFCD03453233
BCP21109
AB15511
PYRIDINE, 4-CHLORO-3-FLUORO-
4-Chloro-3-fluoropyridine, >=95.0%
2546-56-7
4-Chloro-3-fluoropyridine
3-fluoro-4-chloro-pyridine
DTXSID10397332
AM62391
SY007770
AC-14121
CS-W001515
DIBENZYLCYANOCARBONIMIDODITHIOATE
PS-9142
4-chloro-3-fluoro-pyridin
3-Fluoro-4-chloropyridine
EN300-85351
SCHEMBL317186
BEQUUSCRAKEKQM-UHFFFAOYSA-N
AKOS005063628
C3245
4-chloro-3fluoropyridine
W-206953
4-chloro-3-fluoro pyridine
3-Fluor-4-chlor-pyridin
3-fluoro-4-chloropyridine
4-chloro-3-fluoropyridine

MDL Number

MFCD03453233

Customs Code

2933399090

FAQ

What regulatory guidelines apply to 4-Chloro-3-fluoropyridine (CAS: 2546-56-7)?

4-Chloro-3-fluoropyridine (CAS: 2546-56-7) falls under the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) category 4.1 for acute toxicity. It is also subject to regulation under REACH in the EU, which requires registration for substances manufactured or imported in quantities exceeding 1 tonne per manufacturer or importer. In the US, the Environmental Protection Agency (EPA) and FDA may have specific regulations concerning its handling and use in pharmaceuticals and pesticides.

Are there alternatives to 4-Chloro-3-fluoropyridine (CAS: 2546-56-7) in synthesis?

Alternatives to 4-Chloro-3-fluoropyridine (CAS: 2546-56-7) in synthesis include 4-fluoro-3-chloropyridine and 4-bromo-3-fluoropyridine, which can serve similar roles in various chemical reactions. Common alternative reagents include chlorine, bromine, and fluorine in different positions on the pyridine ring, depending on the desired product and reaction conditions.

What is the market or research trend for 4-Chloro-3-fluoropyridine (CAS: 2546-56-7)?

4-Chloro-3-fluoropyridine (CAS: 2546-56-7) is primarily used in the pharmaceutical and agrochemical industries. Recent research trends indicate an increase in its application for the development of antiviral and anticancer drugs. Market trends show steady demand, with slight fluctuations due to regulatory changes and pricing adjustments. Emerging research is focusing on its role in targeted therapy and as a precursor in complex organic syntheses.

How should waste containing 4-Chloro-3-fluoropyridine (CAS: 2546-56-7) be handled?

Waste containing 4-Chloro-3-fluoropyridine (CAS: 2546-56-7) should be collected in appropriate containers lined with absorbent material and labeled for hazardous waste. It should be handled in a well-ventilated area and disposed of through incineration or in a professional hazardous waste facility. Environmental protection measures include wearing protective gear and ensuring that all spills are contained and cleaned up immediately to prevent soil and water contamination. Compliance with local and national regulations is essential.