4-(4-Morpholinyl)aniline

Basic Information

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CAS Number

2524-67-6

Molecular Formula

C10H14N2O

Molecular Weight

178.23 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Melting Point

132-135 °C

Boiling Point

368°C at 760 mmHg

Flash Point

176.4℃

Solubility

Soluble in chloroform, ethyl acetate.

Refractive Index

1.5250 (estimate)

SMILES

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C1COCCN1C2=CC=C(C=C2)N

InChI

InChI=1S/C10H14N2O/c11-9-1-3-10(4-2-9)12-5-7-13-8-6-12/h1-4H,5-8,11H2

InChIKey

PHNDZBFLOPIMSM-UHFFFAOYSA-N

LogP

1.1054

Topological Polar Surface Area

38.489999999999995 Å²

Hydrogen Bond Donor/Acceptor

2 / 3

Complexity

149

Safety Information

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GHS Hazard Pictograms

H315

H319

H335

Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Sensitiveness

Sensitive to air

Synonyms & References

English

4-(Morpholin4yl)phenylamine
CS-B0267
AKOS000100057
10G-307S
BCP13784
6DRK9JS9QD
4-(4-Morpholinyl)aniline #
4-Morpholinoaniline
NSC26334
(4-morpholin-4-ylphenyl)amine
HY-75777
F2107-0001
Z56899028
EINECS 219-760-1
NS00027843
(4-morpholin-4-yl-phenyl)-amine
4-morpholinobenzenamine
STR01950
A23754
4-MORPHOLINOZNILINE
4-(4-morpholinyl)benzenamine
Morpholine, 4-(p-aminophenyl)-
4-morpholin4-ylaniline
4-(morpholino)phenylamine
2524-67-6
TimTec1_002302
N-(4-aminophenyl)-morpholine
CS-M0409
4morpholinoaniline
N-(4-Aminophenyl)morpholine
4-morpholin-4-yl aniline

MDL Number

MFCD00006169

Customs Code

2934999090

FAQ

What are the physical and chemical properties of 4-(4-Morpholinyl)aniline (CAS: 2524-67-6)?

4-(4-Morpholinyl)aniline (CAS: 2524-67-6) is a white crystalline solid with a molecular weight of approximately 204.28 g/mol. It has a solubility of about 24 g/100 mL in water and is slightly soluble in ethanol. The compound is moderately reactive, particularly towards electrophilic aromatic substitution reactions. It is soluble in organic solvents like methanol and acetone. It is not flammable but may form explosive peroxides in storage.

How is 4-(4-Morpholinyl)aniline (CAS: 2524-67-6) typically synthesized?

4-(4-Morpholinyl)aniline is typically synthesized by the reaction of 4-chloroaniline with morpholine in the presence of a base such as sodium hydroxide. The process involves stirring the mixture at room temperature, followed by acidification and recrystallization to obtain the desired product. This method provides a high yield and good selectivity, with a purity of over 95%.

What industries use 4-(4-Morpholinyl)aniline (CAS: 2524-67-6)?

4-(4-Morpholinyl)aniline is used in various industries. In the pharmaceutical industry, it is a precursor for the synthesis of certain drug molecules. In the polymer industry, it can be used as a monomer for the production of polymers. Additionally, it finds applications in the manufacturing of sensors and as a reagent in semiconductor processing.

What precautions should be taken when handling 4-(4-Morpholinyl)aniline (CAS: 2524-67-6)?

When handling 4-(4-Morpholinyl)aniline (CAS: 2524-67-6), it is essential to wear appropriate personal protective equipment (PPE) including gloves and safety glasses. It should be stored in a cool, dry place, away from direct sunlight and heat sources. In case of a spill, it should be cleaned up immediately using appropriate absorbent materials. Handling should be done in a well-ventilated area or fume hood to avoid inhalation of fumes. Refer to the Safety Data Sheet (SDS) for detailed safety instructions.