5-Bromo-3-fluoro-2-hydroxybenzaldehyde

Basic Information

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CAS Number

251300-28-4

Molecular Formula

C7H4BrFO2

Molecular Weight

219.01 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Aldehydes

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

112-116 °C

Boiling Point

226.0±35.0 ºC (760 Torr),

Flash Point

90.5±25.9 ºC,

SMILES

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C1=C(C=C(C(=C1C=O)O)F)Br

InChI

InChI=1S/C7H4BrFO2/c8-5-1-4(3-10)7(11)6(9)2-5/h1-3,11H

InChIKey

YYCQXIWKIRQWHN-UHFFFAOYSA-N

LogP

2.1063

Topological Polar Surface Area

37.3 Å²

Hydrogen Bond Donor/Acceptor

1 / 2

Complexity

153

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

J-015825
AKOS005102494
5-bromanyl-3-fluoranyl-2-oxidanyl-benzaldehyde
CS-W004466
5-Bromo-3-fluorosalicylaldehyde
A817661
Benzaldehyde, 5-bromo-3-fluoro-2-hydroxy-
5-bromo-3-fluoro-2-hydroxybenzaldehyde
YYCQXIWKIRQWHN-UHFFFAOYSA-N
AMY31568
AB16030
5-Bromo-3-fluorosalicylaldehyde, 97%
EN300-66640
DTXSID00381361
SCHEMBL411126
MFCD03788530
Z979493208
SY037898
251300-28-4
8X-0823
5-bromo-3-fluoro-2-hydroxy-benzaldehyde
BP-20082
5-Bromo-3-fluoro-2-hydroxybenzaldehyde
Benzaldehyde,5-bromo-3-fluoro-2-hydroxy-
2-hydroxy-3-fluoro-5-bromobenzaldehyde
4-Bromo-2-fluoro-6-formylphenol
5-bromo--3-fluorosalicylaldehyde
5-BROMO-3-FLUORO-2-HYDROXYBENZENECARBALDEHYDE
PubChem8370
1969AB
SBB095689

MDL Number

MFCD03788530

Customs Code

2913000090

FAQ

What are the physical and chemical properties of 5-Bromo-3-fluoro-2-hydroxybenzaldehyde (CAS: 251300-28-4)?

5-Bromo-3-fluoro-2-hydroxybenzaldehyde is a crystalline solid with a molecular weight of 239.04 g/mol. It is slightly soluble in water and more soluble in organic solvents like ethanol and acetone. Chemically, it is a chromophoric compound, meaning it absorbs light in the ultraviolet and visible regions, making it useful for spectroscopic analysis. It is moderately reactive, particularly towards nucleophiles and reducing agents.

How is 5-Bromo-3-fluoro-2-hydroxybenzaldehyde (CAS: 251300-28-4) typically synthesized?

5-Bromo-3-fluoro-2-hydroxybenzaldehyde is typically synthesized through the bromination of 3-fluoro-2-hydroxybenzaldehyde followed by purification. Commonly, this involves the use of bromine in the presence of a Lewis acid catalyst such as aluminum bromide. The reaction is carried out under anhydrous conditions to ensure high selectivity and yield. The product is then isolated and purified using standard techniques like recrystallization.

What industries use 5-Bromo-3-fluoro-2-hydroxybenzaldehyde (CAS: 251300-28-4)?

5-Bromo-3-fluoro-2-hydroxybenzaldehyde is primarily used in the pharmaceutical industry for the synthesis of various drug intermediates. It also finds applications in the polymer industry for the development of new materials with enhanced properties. Additionally, it is used in the sensor industry for the fabrication of sensors that can detect specific analytes. Its use in semiconductors is less common but can be relevant in special applications requiring high purity.

What precautions should be taken when handling 5-Bromo-3-fluoro-2-hydroxybenzaldehyde (CAS: 251300-28-4)?

When handling 5-Bromo-3-fluoro-2-hydroxybenzaldehyde, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a fume hood to minimize inhalation risks. Spills should be cleaned up using appropriate absorbent materials and followed by the application of a neutralizing agent if necessary. Always consult the Safety Data Sheet (SDS) for specific handling and disposal guidelines. Due to its reactivity, avoid contact with reducing agents and strong bases.