Sincalide | CAS No. 25126-32-3

Sincalide

Basic Information

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CAS Number

25126-32-3

Molecular Formula

C49H62N10O16S3

Molecular Weight

1143.29 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Water Solubility

Soluble in water 1 g/L at 10°C.

Solubility

0.05 M ammonium hydroxide: 1 mg/mL, clear, colorless

Specific Rotation

D23 -18.4° (c = 0.7 in 1N NH3)

SMILES

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CSCCC(C(=O)NCC(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(CCSC)C(=O)NC(CC(=O)O)C(=O)NC(CC3=CC=CC=C3)C(=O)N)NC(=O)C(CC4=CC=C(C=C4)OS(=O)(=O)O)NC(=O)C(CC(=O)O)N

InChI

InChI=1S/C49H62N10O16S3/c1-76-18-16-34(55-47(69)37(58-44(66)32(50)23-41(61)62)21-28-12-14-30(15-13-28)75-78(72,73)74)45(67)53-26-40(60)54-38(22-29-25-52-33-11-7-6-10-31(29)33)48(70)56-35(17-19-77-2)46(68)59-39(24-42(63)64)49(71)57-36(43(51)65)20-27-8-4-3-5-9-27/h3-15,25,32,34-39,52H,16-24,26,50H2,1-2H3,(H2,51,65)(H,53,67)(H,54,60)(H,55,69)(H,56,70)(H,57,71)(H,58,66)(H,59,68)(H,61,62)(H,63,64)(H,72,73,74)/t32-,34-,35-,36-,37-,38-,39-/m0/s1

InChIKey

IZTQOLKUZKXIRV-YRVFCXMDSA-N

LogP

-1.3294000000000055

Topological Polar Surface Area

426.7999999999999 Å²

Hydrogen Bond Donor/Acceptor

15 / 26

Complexity

2180

Synonyms & References

English

MFCD00079849
Cholecystokinin Pancreozymin C-Terminal Octapeptide
SINCALIDE [USP IMPURITY]
(3S,6S,9S,15S,18S,21S)-9-((1H-indol-3-yl)methyl)-21-amino-3-(((S)-1-amino-1-oxo-3-phenylpropan-2-yl)carbamoyl)-6,15-bis(2-(methylthio)ethyl)-5,8,11,14,17,20-hexaoxo-18-(4-(sulfooxy)benzyl)-4,7,10,13,16,19-hexaazatricosane-1,23-dioic acid
DB09142
L-.ALPHA.-ASPARTYL-O-SULFO-L-TYROSYL-L-METHIONYLGLYCYL-L-TRYPTOPHYL-L-METHIONYL-L-.ALPHA.-ASPARTYL-L-PHENYLALANINAMIDE
CHEBI:135946
cholecystokinin C-terminal octapeptide
(3S,6S,9S,15S,18S,21S)-9-((1H-indol-3-yl)methyl)-21-amino-3-((S)-1-amino-1-oxo-3-phenylpropan-2-ylcarbamoyl)-6,15-bis(2-(methylthio)ethyl)-5,8,11,14,17,20-hexaoxo-18-(4-(sulfooxy)benzyl)-4,7,10,13,16,19-hexaazatricosane-1,23-dioic acid
BDBM21147
DTXCID4028543
CAS-25126-32-3
CCK-8(SO3)
Kinevac
L-Aspartyl-L-tyrosyl-L-methionylglycyl-L-tryptophyl-L-methionyl-L-aspartylphenyl-L-alaninamide Hydrogen Sulfate(ester)
Sincalida
D05845
CS-5963
H-Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2
SINCALIDE [USAN]
Sincalide (USAN:USP:INN:BAN)
SQ19844
Caerulein, 1-de(5-oxo-L-proline)-2-de-L-glutamine-5-L-methionine-
IZTQOLKUZKXIRV-YRVFCXMDSA-N
SINCALIDE [MART.]
Human CCK-8
Sincalidum
Cholecystokinin-pancreozymin
Sincalidum [INN-Latin]
(3S)-3-[(2S)-2-[(2S)-2-{2-[(2S)-2-[(2S)-2-[(2S)-2-amino-3-carboxypropanamido]-3-[4-(sulfooxy)phenyl]propanamido]-4-(methylsulfanyl)butanamido]acetamido}-3-(1H-indol-3-yl)propanamido]-4-(methylsulfanyl)butanamido]-3-{[(1S)-1-carbamoyl-2-phenylethyl]carbamoyl}propanoic acid
Sincalida (INN-Spanish)

MDL Number

MFCD00079849

FAQ

What is Sincalide (CAS: 25126-32-3)?

Sincalide (CAS: 25126-32-3) is a synthetic octapeptide used primarily as a diagnostic tool for assessing pancreatic function. It is composed of eight amino acids and is administered as a fast-acting octapeptide that mimics the natural hormone secretin.

What are the main uses of Sincalide (CAS: 25126-32-3)?

Sincalide (CAS: 25126-32-3) is mainly used in medical diagnostics to evaluate pancreatic exocrine function. It stimulates the pancreas to release bicarbonate and digestive enzymes, which are then measured in the duodenal aspirate to assess pancreatic health.

Is Sincalide (CAS: 25126-32-3) safe?

Sincalide (CAS: 25126-32-3) is generally considered safe when used under medical supervision. However, like any medication, it can cause side effects such as nausea, vomiting, and allergic reactions. It is important to follow medical guidelines and use appropriate protective measures during administration.

How should Sincalide (CAS: 25126-32-3) be stored?

Sincalide (CAS: 25126-32-3) should be stored at a temperature between 2°C and 8°C (36°F to 46°F) to maintain its stability and potency. It should be kept away from direct sunlight and protected from humidity to prevent degradation. The medication should be stored in a tightly closed container to ensure its integrity.