Catharanthine | CAS No. 2468-21-5

Catharanthine

Basic Information

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CAS Number

2468-21-5

Molecular Formula

C21H24N2O2

Molecular Weight

336.43 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Physical State

White powder

Melting Point

126-128°C

Boiling Point

491.5°C at 760 mmHg

Flash Point

251.1ºC

Solubility

DMSO: soluble5mg/mL (clear solution; warmed)

Refractive Index

1.6500 (estimate)

Specific Rotation

+30 to +38° (c=0.5, CDCl3)

SMILES

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CCC1=C[C@@H]2CN3[C@H]1[C@@](C2)(C(=O)OC)c1[nH]c2c(c1CC3)cccc2

InChI

InChI=1S/C21H24N2O2/c1-3-14-10-13-11-21(20(24)25-2)18-16(8-9-23(12-13)19(14)21)15-6-4-5-7-17(15)22-18/h4-7,10,13,19,22H,3,8-9,11-12H2,1-2H3/t13-,19+,21-/m0/s1

InChIKey

CMKFQVZJOWHHDV-NQZBTDCJSA-N

LogP

3.175300000000002

pKa

6.8(at 25℃)

Topological Polar Surface Area

45.33 Å²

Hydrogen Bond Donor/Acceptor

1 / 4

Complexity

603

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Storage Conditions

2-8℃

Synonyms & References

English

Catharanthine
(+)-CATHRANTHINE
(+)-3,4-Didehydrocoronaridine
CatharanthineTartrate
EpimedinA
(2α,5β,6α,18β)-3,4-Didehydroibogamine-18-carboxylic acid methyl ester
catharanthin
Catharanthine Sulphate
CatharanthineSulfateBase
catharantine
catharinthine
catharintine
Vincaleukoblastine
Catharanthine Tartrat
Methyl (2alpha,5beta,6alpha)-3,4-didehydroibogamine-18beta-carboxylate
NSC102004
CATHARANTHINE HCL
Oprea1_075759
Catharanthine, monohydrochloride
CMKFQVZJOWHHDV-UHFFFAOYSA-N
STK370495
Methyl 3,4-dide
(+)-Catharanthine,Catharanthin,(+)-3,4-Didehydrocoronaridine

MDL Number

MFCD01753356

FAQ

What is Catharanthine (CAS: 2468-21-5)?

Catharanthine (CAS: 2468-21-5) is a quinolizidine alkaloid derived from the Vinca rosea plant. It has the chemical formula C19H21NO4 and is a yellow solid at room temperature. Known for its pharmacological properties, Catharanthine is used as a precursor in the synthesis of various medicinal compounds and exhibits antioxidant and anti-inflammatory characteristics.

What are the main uses of Catharanthine (CAS: 2468-21-5)?

Catharanthine (CAS: 2468-21-5) is primarily utilized in pharmaceutical research for developing drugs targeting cardiovascular and neurodegenerative conditions. It serves as a key intermediate in the production of vincamine and other alkaloids. Additionally, it is studied for its potential applications in medicinal chemistry and as a natural compound in bioactive research.

Is Catharanthine (CAS: 2468-21-5) safe?

Catharanthine (CAS: 2468-21-5) is generally considered safe when handled properly in controlled environments. However, it may cause irritation to skin and eyes, and ingestion can be toxic. Safety protocols include wearing protective gear, ensuring proper ventilation, and adhering to OSHA guidelines. Always follow established safety standards for handling alkaloids.

How should Catharanthine (CAS: 2468-21-5) be stored?

Catharanthine (CAS: 2468-21-5) should be stored in a cool, dry place below 25°C, away from light. Keep in airtight, moisture-proof containers to maintain stability. Avoid exposure to air and humidity to prevent degradation. Store in a secure location to ensure safety and prolong shelf life.