(2R)-2-(6-Methoxy-2-naphthyl)propanoic acid

Basic Information

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CAS Number

23979-41-1

Molecular Formula

C14H14O3

Molecular Weight

230.26 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Melting Point

156-158 °C

Boiling Point

403.9°C at 760 mmHg

SMILES

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CC(C1=CC2=C(C=C1)C=C(C=C2)OC)C(=O)O

InChI

InChI=1S/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16)/t9-/m1/s1

InChIKey

CMWTZPSULFXXJA-SECBINFHSA-N

LogP

3.036500000000001

Topological Polar Surface Area

46.53 Å²

Hydrogen Bond Donor/Acceptor

1 / 3

Complexity

277

Safety Information

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GHS Hazard Pictograms

H302

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

Synonyms & References

English

NAPROXEN SODIUM IMPURITY G [EP IMPURITY]
Naproxen, (-)-
MFCD00870716
Prestwick0_000045
(R)-2-(6-Methoxynaphthalen-2-yl)propanoicacid
2-NAPHTHALENEACETIC ACID, 6-METHOXY-.ALPHA.-METHYL-, (.ALPHA.R)-
(R)-Naproxen
AC-25534
23979-41-1
HY-15031
NAPROXEN IMPURITY G [EP IMPURITY]
DTXSID00904711
EINECS 245-966-6
(R)-2-(6methoxynaphthalen-2-yl)propanoic acid
Prestwick1_000045
UNII-484XV9323P
NPX
(R)-6-Methoxy-alpha-methylnaphthalene-1-acetic acid
EN300-139794
(2R)-2-(6-Methoxynaphthalen-2-yl)propanoic Acid ((R)-Naproxen)
(-)-Naproxen
CS-W019918
BDBM50533571
CHEBI:94583
AKOS016842784
l-Naproxen
SCHEMBL42434
r-naproxen
(R)-(-)-Naproxen
BSPBio_000922
PS-7719

MDL Number

MFCD00870716

Customs Code

2918990090

FAQ

What are the physical and chemical properties of (2R)-2-(6-Methoxy-2-naphthyl)propanoic acid (CAS: 23979-41-1)?

(2R)-2-(6-Methoxy-2-naphthyl)propanoic acid is a solid with a crystalline form. Its molecular weight is approximately 224.25 g/mol. This compound has a solubility of about 10 mg/mL in water and is slightly soluble in ethanol. It is reactive towards basic conditions and shows moderate acidity. The compound is stable under normal storage conditions but should be protected from moisture and air oxidation.

How is (2R)-2-(6-Methoxy-2-naphthyl)propanoic acid (CAS: 23979-41-1) typically synthesized?

(2R)-2-(6-Methoxy-2-naphthyl)propanoic acid is typically synthesized via a multi-step process involving the reaction of 6-methoxy-2-naphthylmagnesium bromide with propionoyl chloride. The reaction is catalyzed by a base such as triethylamine, and the product undergoes a subsequent acid work-up to yield the desired acid. This method provides good yield and selectivity.

What industries use (2R)-2-(6-Methoxy-2-naphthyl)propanoic acid (CAS: 23979-41-1)?

(2R)-2-(6-Methoxy-2-naphthyl)propanoic acid is used in the pharmaceutical industry for the synthesis of drug intermediates. It also finds application in the production of organic semiconductors and as a precursor in the development of novel materials for sensors and polymers. Its unique chemical properties make it valuable in these sectors.

What precautions should be taken when handling (2R)-2-(6-Methoxy-2-naphthyl)propanoic acid (CAS: 23979-41-1)?

When handling (2R)-2-(6-Methoxy-2-naphthyl)propanoic acid, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up immediately using appropriate absorbent materials. Always refer to the Safety Data Sheet (SDS) for detailed handling and emergency procedures.