Compound Q&A

How is (2R)-2-(6-Methoxy-2-naphthyl)propanoic acid (CAS: 23979-41-1) typically synthesized?

Answer

(2R)-2-(6-Methoxy-2-naphthyl)propanoic acid
(2R)-2-(6-Methoxy-2-naphthyl)propanoic acid is typically synthesized via a multi-step process involving the reaction of 6-methoxy-2-naphthylmagnesium bromide with propionoyl chloride. The reaction is catalyzed by a base such as triethylamine, and the product undergoes a subsequent acid work-up to yield the desired acid. This method provides good yield and selectivity.

About

CAS No 23979-41-1
English Name (2R)-2-(6-Methoxy-2-naphthyl)propanoic acid
Molecular Formula C14H14O3
Molecular Weight 230.26299999999998 g/mol
SMILES CC(C1=CC2=C(C=C1)C=C(C=C2)OC)C(=O)O
InChIKey CMWTZPSULFXXJA-SECBINFHSA-N
Last Updated: 2025-10-17 07:35

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