Terazosin EP Impurity A (Alfuzosin EP Impurity B, Prazosin EP Impurity A)

Basic Information

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CAS Number

23680-84-4

Molecular Formula

C10H10ClN3O2

Molecular Weight

239.66 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

262-268 °C (dec.)

Boiling Point

374.0±42.0 °C at 760 mmHg

Flash Point

180.0±27.9 °C

Refractive Index

1.5500 (estimate)

Vapor Pressure

0.0±0.8 mmHg at 25°C

SMILES

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COC1=C(C=C2C(=C1)C(=NC(=N2)Cl)N)OC

InChI

InChI=1S/C10H10ClN3O2/c1-15-7-3-5-6(4-8(7)16-2)13-10(11)14-9(5)12/h3-4H,1-2H3,(H2,12,13,14)

InChIKey

HWIIAAVGRHKSOJ-UHFFFAOYSA-N

LogP

1.8825999999999998

Topological Polar Surface Area

70.26 Å²

Hydrogen Bond Donor/Acceptor

2 / 5

Complexity

244

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

4-amino-2chloro-6,7-dimethoxy quinazoline
TERAZOSIN HYDROCHLORIDE DIHYDRATE IMPURITY A [EP IMPURITY]
BB 0257419
Tox21_113801
SCHEMBL611438
23680-84-4
4-Quinazolinamine, 2-chloro-6,7-dimethoxy-
Doxazosin impurity F, European Pharmacopoeia (EP) Reference Standard
EN300-66004
FT-0620860
AKOS000264944
4-Amino-2-chloro-6,7-dimethoxyquinazoline
CHEMBL3561187
SR-01000197509-2
BIDD:GT0452
SY008892
SR-01000197509-1
Z1033088242
4-amino-2-chloro-6,7-dimethoxy-quinazoline
BCP28790
NCGC00253677-01
EC 245-821-7
Prazosin impurity A
2-chloro-6,7-dimethoxy-4-aminoquinazoline
AE-848/31926053
2-Chloro-6,7-dimethoxyquinazolin-4-amine
PRAZOSIN HYDROCHLORIDE IMPURITY A [EP IMPURITY]
CAS-23680-84-4
4-amino-2-chloro-6,7-dimethoxy quinazoline
W-107385
BDBM626199

MDL Number

MFCD00051734

Customs Code

2933990090

FAQ

What is Terazosin EP Impurity A (CAS: 23680-84-4)?

Terazosin EP Impurity A (CAS: 23680-84-4) is a chemical compound identified as an impurity in pharmaceutical preparations of terazosin, alfuzosin, and prazosin. It is structurally related to these alpha-1 adrenergic receptor antagonists and is often analyzed during drug quality control to ensure compliance with safety and purity standards. Its exact chemical formula is not publicly detailed, but it is characterized as a piperazine derivative with pyrazole and trifluoroethyl groups.

What are the main uses of Terazosin EP Impurity A (CAS: 23680-84-4)?

Terazosin EP Impurity A (CAS: 23680-84-4) is primarily used in pharmaceutical research and quality control to identify and quantify impurities in drugs like terazosin, which treats hypertension and benign prostatic hyperplasia. It also serves as a reference standard for analytical testing, ensuring the safety and efficacy of these medications. Its role is critical in regulatory compliance and drug development processes.

Is Terazosin EP Impurity A (CAS: 23680-84-4) safe?

Terazosin EP Impurity A (CAS: 23680-84-4) is considered safe when handled according to standard laboratory protocols and within regulated limits in pharmaceutical products. As an impurity, it is not intended for therapeutic use but is monitored to ensure minimal presence in final drug formulations. Precautions include wearing gloves, eye protection, and ensuring proper ventilation to avoid exposure. Safety standards align with OSHA and EPA guidelines for chemical handling.

How should Terazosin EP Impurity A (CAS: 23680-84-4) be stored?

Terazosin EP Impurity A (CAS: 23680-84-4) should be stored in a cool, dry place, away from light, and in a sealed container to maintain stability. It is typically kept at 2-8°C (refrigerated) to prevent degradation. Avoid exposure to moisture and heat, and ensure storage conditions comply with manufacturer specifications to preserve its chemical integrity for analytical purposes.