Difluprednate | CAS No. 23674-86-4

Difluprednate

Basic Information

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CAS Number

23674-86-4

Molecular Formula

C27H34F2O7

Molecular Weight

508.56 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ketones

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Fine Chemicals Surfactants Anionic Surfactants

Fine Chemicals Specialty Chemicals UV Stabilizers

Polymers and Plastics Thermoplastics Polyolefins

Basic Physical Properties

Melting Point

191.0 to 195.0 deg-C

Specific Rotation

D22 +31.7° (c = 0.5 in dioxane)

SMILES

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CCCC(=O)OC1(CCC2C1(CC(C3(C2CC(C4=CC(=O)C=CC43C)F)F)O)C)C(=O)COC(=O)C

InChI

InChI=1S/C27H34F2O7/c1-5-6-23(34)36-26(22(33)14-35-15(2)30)10-8-17-18-12-20(28)19-11-16(31)7-9-24(19,3)27(18,29)21(32)13-25(17,26)4/h7,9,11,17-18,20-21,32H,5-6,8,10,12-14H2,1-4H3/t17-,18-,20-,21-,24-,25-,26-,27-/m0/s1

InChIKey

WYQPLTPSGFELIB-JTQPXKBDSA-N

LogP

3.5195000000000025

Topological Polar Surface Area

106.97000000000003 Å²

Hydrogen Bond Donor/Acceptor

1 / 7

Complexity

1050

Safety Information

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GHS Hazard Pictograms

H361

Hazard Statement

H361 Suspected of damaging fertility or the unborn child
Reproductive toxicity

Synonyms & References

English

MLS001148580
Difluprednato
21-(Acetyloxy)-6,9-difluoro-11-hydroxy-17-(1-oxobutoxy)pregna-1,4-diene-3,20-dione (6alpha,11beta)-
DIFLUPREDNATE [MART.]
23674-86-4
difluprednate
MLS000028663
Durezol (TN)
'MLS001148580-01!6ALPHA,9ALPHA-DIFLUOROPREDNISOLONE 21-ACETATE 17-BUTYRATE'
Difluprednate Ophthalmic Emulsion
Pregna-1,4-diene-3,20-dione,21-(acetyloxy)-6,9-difluoro-11-hydroxy-17-(1-oxobutoxy)-, (6a,11b)-
[(6S,8S,9R,10S,11S,13S,14S,17R)-17-(2-acetyloxyacetyl)-6,9-difluoro-11-hydroxy-10,13-dimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] butanoate
st60-1
(1R,2S,8S,10S,11S,14R,15S,17S)-14-[2-(acetyloxy)acetyl]-1,8-difluoro-17-hydroxy-2,15-dimethyl-5-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-14-yl butanoate
(6alpha,11beta)-21-(Acetyloxy)-6,9-difluoro-11-hydroxy-17-(1-oxobutoxy)pregna-1,4-diene-3,20-dion
6ALPHA,9ALPHA-DIFLUOROPREDNISOLONE 21-ACETATE 17-BUTYRATE
(1R,3aS,3bS,5S,9aS,9bR,10S,11aS)-1-[2-(acetyloxy)acetyl]-5,9b-difluoro-10-hydroxy-9a,11a-dimethyl-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,7H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl butanoate
AB00383058_10
DTXSID0046773
SCHEMBL4580
Difluoroprednisolone butyrate acetate
NCGC00168749-01
Difluprednate Ophthalmic
HMS2231D18
Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-6,9-difluoro-11-hydroxy-17-(1-oxobutoxy)-, (6alpha,11beta)-
SMR000058924
UNII-S8A06QG2QE
WYQPLTPSGFELIB-JTQPXKBDSA-N
DIFLUPREDNATE [MI]
CCG-269762
Difluprednatum (INN-Latin)

MDL Number

MFCD00214273

FAQ

What regulatory guidelines apply to Difluprednate (CAS: 23674-86-4)?

Difluprednate (CAS: 23674-86-4) falls under the regulatory guidelines of the Chemicals Regulation Directive (CRD) in the European Union and REACH regulations. It is also subject to the Toxic Substances Control Act (TSCA) in the United States. Additionally, it is classified under the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) as a skin and eye irritant.

Are there alternatives to Difluprednate (CAS: 23674-86-4) in synthesis?

For synthesis, alternatives to Difluprednate include similar corticosteroids such as dexamethasone and hydrocortisone. Isomers like difluprednate itself and analogs like difluprednate sodium can also be considered. Common alternative reagents include corticosteroid precursors and other steroidal compounds.

What is the market or research trend for Difluprednate (CAS: 23674-86-4)?

The market for Difluprednate (CAS: 23674-86-4) is growing due to its use in ocular inflammatory conditions. Research trends include its efficacy and safety in various clinical settings, as well as its potential for use in other dermatological applications. Recent studies focus on its pharmacokinetics and bioavailability.

How should waste containing Difluprednate (CAS: 23674-86-4) be handled?

Waste containing Difluprednate (CAS: 23674-86-4) should be collected in appropriate containers and disposed of through a hazardous waste management facility. Incineration is a common method, as it ensures proper destruction of the compound. Environmental precautions include minimizing spillage and following local regulations for hazardous waste disposal.