4-Fluoro-3-(trifluoromethyl)aniline

Basic Information

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CAS Number

2357-47-3

Molecular Formula

C7H5F4N

Molecular Weight

179.12 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Boiling Point

208°C

Refractive Index

n20/D 1.466(lit.)

SMILES

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C1=CC(=C(C=C1N)C(F)(F)F)F

InChI

InChI=1S/C7H5F4N/c8-6-2-1-4(12)3-5(6)7(9,10)11/h1-3H,12H2

InChIKey

PGFQDLOMDIBAPY-UHFFFAOYSA-N

LogP

2.4267000000000003

Topological Polar Surface Area

26.02 Å²

Hydrogen Bond Donor/Acceptor

2 / 1

Complexity

156

Safety Information

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GHS Hazard Pictograms

H302

H312

H315

H319

H332

H335

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H312 Harmful in contact with skin
Acute toxicity, dermal

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H332 Harmful if inhaled
Acute toxicity, inhalation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class 6.1 Class 6.1

Synonyms & References

English

4-fluoro-3-trifluoromethyl aniline
Benzenamine, 4-fluoro-3-(trifluoromethyl)-
.ALPHA.,.ALPHA.,.ALPHA.,4-TETRAFLUORO-3-METHYLANILINE
UNII-V5584X2CTL
DTXSID1022184
4-fluoro-3-trifluoromethyl-aniline
AC-2636
AKOS005172622
V5584X2CTL
EN300-50846
4-Tetrafluoro-m-toluidine
AM20030407
A1164
FT-0619981
InChI=1/C7H5F4N/c8-6-2-1-4(12)3-5(6)7(9,10)11/h1-3H,12H2
PS-8549
NSC 10326
4-Fluoro-3-(trifluoromethyl)aniline
NSC-10326
4-floro-3-trifloromethyl aniline
a,a,a,4-Tetrafluoro-m-toluidine
EINECS 219-095-7
NSC10326
MFCD00007834
alpha,alpha,alpha-4-Tetrafluoro-m-toluidine
4-Fluoro-3-trifluoromethylaniline
5-Amino-2-fluorobenzotrifluoride
alpha,alpha,alpha,4-Tetrafluoro-m-toluidine
2-fluoro-5-amino benzotrifluoride
4-fluoro-3-(trifluoromethyl)-aniline
NS00049513

MDL Number

MFCD00007834

Customs Code

29214300

FAQ

What regulatory guidelines apply to 4-Fluoro-3-(trifluoromethyl)aniline (CAS: 2357-47-3)?

4-Fluoro-3-(trifluoromethyl)aniline (CAS: 2357-47-3) is regulated under the Globally Harmonized System of Classification and Labeling of Chemicals (GHS), REACH regulations in the European Union, and by the FDA and EPA in the United States. Specific requirements include proper labeling, hazard communication, and safe handling practices to ensure occupational and environmental safety.

Are there alternatives to 4-Fluoro-3-(trifluoromethyl)aniline (CAS: 2357-47-3) in synthesis?

While 4-Fluoro-3-(trifluoromethyl)aniline (CAS: 2357-47-3) is a critical compound in certain applications, alternatives include 4-chloro-3-(trifluoromethyl)aniline and 4-bromo-3-(trifluoromethyl)aniline. These can be used as substitutes in some synthetic pathways, depending on the desired product and reaction conditions.

What is the market or research trend for 4-Fluoro-3-(trifluoromethyl)aniline (CAS: 2357-47-3)?

Market trends for 4-Fluoro-3-(trifluoromethyl)aniline (CAS: 2357-47-3) are driven by its use in pharmaceuticals, pesticides, and organic synthesis. Research is focusing on its role in drug discovery and development, with increasing interest in its potential applications in medicinal chemistry and materials science.

How should waste containing 4-Fluoro-3-(trifluoromethyl)aniline (CAS: 2357-47-3) be handled?

Waste containing 4-Fluoro-3-(trifluoromethyl)aniline (CAS: 2357-47-3) should be collected in appropriate containers and disposed of through incineration in specialized facilities or by a professional hazardous waste disposal service. Environmental precautions include ensuring no release into the air or water, and following all local and international disposal regulations.