Nefopam hydrochloride

Basic Information

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CAS Number

23327-57-3

Molecular Formula

C17H20ClNO

Molecular Weight

289.81 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Physical State

Powder

Melting Point

251°C

Boiling Point

369.5°Cat760mmHg

Density

1.064

Flash Point

109°C

Solubility

H2O: soluble5mg/mL, clear

SMILES

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CN1CCOC(C2=CC=CC=C2C1)C3=CC=CC=C3.Cl

InChI

InChI=1S/C17H19NO.ClH/c1-18-11-12-19-17(14-7-3-2-4-8-14)16-10-6-5-9-15(16)13-18;/h2-10,17H,11-13H2,1H3;1H

InChIKey

CNNVSINJDJNHQK-UHFFFAOYSA-N

LogP

3.659800000000003

Topological Polar Surface Area

12.47 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Complexity

274

Safety Information

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GHS Hazard Pictograms

H301

Hazard Statement

H301 Toxic if swallowed
Acute toxicity, oral

Hazard Class

Class 6.1 Class 6.1

Toxicity

LD50 in mice, rats (mg/kg): 119, 178 orally; 44.5, 28 i.v. (Baltes)

Synonyms & References

English

HMS1568N19
NEFOPAM HYDROCHLORIDE [WHO-DD]
Fenazoxine hydrochloride; Lenipan; Leoplexamin; Nefopam HCl
DTXCID5025441
Nefopam Hydrochloride 1.0 mg/ml in Methanol (as free base)
R 738
NEFOPAM HYDROCHLORIDE [MART.]
CS-4579
MLS001240198
5-Methyl-1-phenyl-3,4,5,6-tetrahydro-1H-2,5-benzoxazocine hydrochloride
NSC 757856
1H-2,5-BENZOXAZOCINE, 5-METHYL-1-PHENYL-3,4,5,6-TETRAHYDRO-, HYDROCHLORIDE
D05133
SR-01000388442-1
FT-0630499
SMR000514529
69319-31-9
Nefopam hydrochloride, >=98% (HPLC)
CAS#23327-57-3
5-Methyl-1-phenyl-3,4,5,6-tetrahydro-1H-benzo[f][1,4]oxazocine hydrochloride
Nefopam hydrochloride [USAN]
Nefopam hydrochloride
Nefopam (hydrochloride)
CAS-23327-57-3
Fenazoxine hydrochloride
Oxadol
Nefopan hydrochloride
MLS001210851
23327-57-3 (HCl)
AKOS015845828
Nefopam hydrochloride (USAN)

MDL Number

MFCD00012750

Customs Code

2942000000

FAQ

What is Nefopam hydrochloride (CAS: 23327-57-3)?

Nefopam hydrochloride (CAS: 23327-57-3) is a centrally acting analgesic that is used to manage moderate to severe pain. It is a white to practically white crystalline powder with a molecular formula of C14H17NO2·HCl, and a molecular weight of 278.75.

What are the main uses of Nefopam hydrochloride (CAS: 23327-57-3)?

Nefopam hydrochloride (CAS: 23327-57-3) is primarily used in the treatment of moderate to severe pain, particularly in cases where other analgesics are not effective. It is also used in the management of pain associated with chronic conditions like osteoarthritis and in postoperative pain management.

Is Nefopam hydrochloride (CAS: 23327-57-3) safe?

Nefopam hydrochloride (CAS: 23327-57-3) is generally considered safe when used as directed. However, it can cause side effects such as dizziness, nausea, and sedation. Users should be cautious and follow the prescribed dosage instructions to avoid potential adverse effects.

How should Nefopam hydrochloride (CAS: 23327-57-3) be stored?

Nefopam hydrochloride (CAS: 23327-57-3) should be stored in a cool, dry place, preferably between 15°C and 30°C (59°F and 86°F). It should be protected from light and stored in a tightly closed container to prevent moisture and degradation. Avoid storing it in direct sunlight or high humidity environments.