1-(4-Chlorobenzyl)piperazine

Basic Information

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CAS Number

23145-88-2

Molecular Formula

C11H15ClN2

Molecular Weight

210.71 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Boiling Point

106°C/0.1mmHg

Refractive Index

n20/D 1.5580(lit.)

Vapor Pressure

0.0±0.6 mmHg at 25°C

SMILES

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C1CN(CCN1)CC2=CC=C(C=C2)Cl

InChI

InChI=1S/C11H15ClN2/c12-11-3-1-10(2-4-11)9-14-7-5-13-6-8-14/h1-4,13H,5-9H2

InChIKey

GSJXJZOWHSTWOX-UHFFFAOYSA-N

LogP

1.7451999999999996

Topological Polar Surface Area

15.27 Å²

Hydrogen Bond Donor/Acceptor

1 / 2

Complexity

161

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H314 Causes severe skin burns and eye damage
Skin corrosion/irritation

Hazard Class

Class 8 Class 8

Sensitiveness

Sensitive to air

Synonyms & References

English

Piperazine,1-[(4-chlorophenyl)methyl]-,hydrochloride(1:1)
GSJXJZOWHSTWOX-UHFFFAOYSA-N
4-Chlorobenzylpiperazine
[(4-chlorophenyl)methyl]piperazine
RS-1010
SCHEMBL208118
Oprea1_021072
BRD-K73917901-003-01-6
FS-1567
1-(4-Chlorobenzyl)piperazine
CCG-17703
C3184
1-(4-chloro benzyl)piperazine
MFCD00040791
23145-88-2
1-(4-Chlorobenzyl)piperazine, 98%
Norhomochlorcyclizine
Cetirizine Impurity A,(S)
1-(4-Chlorobenzyl)-piperazine
Piperazine, 1-((4-chlorophenyl)methyl)-
NCIOpen2_005665
1-p-chlorobenzyl-piperazine
Oprea1_297115
EU-0006924
1-(4-Chlorobenzyl)piperazine, puriss., 98%
N-(4-chlorobenzyl)piperazine
1-[(4-chlorophenyl)methyl]piperazine
Chlorbenzylpiperazine
AKOS000198972
BB 0217768
Z56347550

MDL Number

MFCD00040791

Customs Code

2933599090

FAQ

What regulatory guidelines apply to 1-(4-Chlorobenzyl)piperazine (CAS: 23145-88-2)?

1-(4-Chlorobenzyl)piperazine (CAS: 23145-88-2) falls under the classification of chemicals requiring regulatory oversight. Under the Globally Harmonized System of Classification and Labelling of Chemicals (GHS), it is classified as a skin and eye irritant. It is also subject to reporting under the REACH regulations in the European Union. In the United States, it is regulated by the Environmental Protection Agency (EPA) and may require registration, and by the FDA for any pharmaceutical applications.

Are there alternatives to 1-(4-Chlorobenzyl)piperazine (CAS: 23145-88-2) in synthesis?

Several alternatives can be used in the synthesis of 1-(4-Chlorobenzyl)piperazine (CAS: 23145-88-2). For instance, using 4-aminobenzylpiperazine with chlorine substitution can serve as a precursor. Other reagents such as 4-chlorobenzyl chloride and piperazine can also be substituted. These alternatives provide similar functionality while potentially offering different reactivity profiles and synthetic convenience.

What is the market or research trend for 1-(4-Chlorobenzyl)piperazine (CAS: 23145-88-2)?

The market for 1-(4-Chlorobenzyl)piperazine (CAS: 23145-88-2) is largely driven by its use in pharmaceuticals, particularly as an agonist in receptor studies. Research trends suggest continued interest in its role as a tool compound for studying G-protein coupled receptors. Additionally, there is growing interest in its potential use in drug discovery and development, particularly for neurological and psychiatric disorders.

How should waste containing 1-(4-Chlorobenzyl)piperazine (CAS: 23145-88-2) be handled?

Waste containing 1-(4-Chlorobenzyl)piperazine (CAS: 23145-88-2) should be collected in appropriate containers and stored in a secure location to prevent environmental contamination. It is recommended to incinerate the waste in an appropriately equipped facility to ensure complete destruction. Alternatively, professional waste disposal services can handle the waste, ensuring compliance with local and international regulations. Proper environmental protection precautions, such as wearing protective gear and following safety protocols, are essential during the handling and disposal process.