Neferine | CAS No. 2292-16-2

Neferine

Basic Information

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CAS Number

2292-16-2

Molecular Formula

C38H44N2O6

Molecular Weight

624.78 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Physical State

White powder

Solubility

DMSO: >15mg/mL

SMILES

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CN1CCC2=CC(=C(C=C2C1CC3=CC=C(C=C3)OC)OC4=C(C=CC(=C4)CC5C6=CC(=C(C=C6CCN5C)OC)OC)O)OC

InChI

InChI=1S/C38H44N2O6/c1-39-15-14-27-21-36(44-5)38(23-30(27)31(39)17-24-7-10-28(42-3)11-8-24)46-34-19-25(9-12-33(34)41)18-32-29-22-37(45-6)35(43-4)20-26(29)13-16-40(32)2/h7-12,19-23,31-32,41H,13-18H2,1-6H3/t31-,32-/m1/s1

InChIKey

MIBATSHDJRIUJK-ROJLCIKYSA-N

LogP

6.762300000000008

Topological Polar Surface Area

72.86000000000001 Å²

Hydrogen Bond Donor/Acceptor

1 / 8

Complexity

933

Safety Information

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Storage Conditions

-20℃

Synonyms & References

English

AKOS016002114
2292-16-2
DTXSID40177462
4-[(6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-1-yl)methyl]-2-[[6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methyl-3,4-dihydro-1H-isoquinolin-7-yl]oxy]phenol
4-[[(1R)-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-1-yl]methyl]-2-[[(1R)-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methyl-3,4-dihydro-1H-isoquinolin-7-yl]oxy]phenol
CHEBI:176257
Phenol, 4-[[(1S)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl]methyl]-2-[[(1R)-1,2,3,4-tetrahydro-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methyl-7-isoquinolinyl]oxy]-
1ST157233
Q-100292
MIBATSHDJRIUJK-ROJLCIKYSA-N
Neferin
SCHEMBL12807595
CHEMBL455560
Neferine
A878384
BRN 1523459
(-)-Neferine
Phenol, 4-((1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl)methyl)-2-((1,2,3,4-tetrahydro-6-methoxy-1-((4-methoxyphenyl)methyl)-2-methyl-7-isoquinolinyl)oxy)-
4-[[(1R)-6,7-Dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-1-yl]methyl]-2-[[(1R)-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methyl-3,4-dihydro-1H-isoquinolin-7-yl]oxy]phenol
4-{[(1r)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl}-2-{[(1r)-6-methoxy-1-(4-methoxybenzyl)-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl]oxy}phenol
Phenol,4-((1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl)methyl)-2-((1,2,3,4-tetrahydro-6-methoxy-1-((4-methoxyphenyl)methyl)-2-methyl-7-isoquinolinyl)oxy)
(-)-Neferine,4''-O-Methylliensinine,Methylliensinine,Neferin

MDL Number

MFCD01707128

FAQ

What is Neferine (CAS: 2292-16-2)?

Neferine is a natural alkaloid derived from the seeds of the plant *Thevetia peruviana*. It has the chemical formula C21H25NO11 and is known for its anti-inflammatory, antioxidant, and neuroprotective properties. Neferine is a glycoside of neriine and is commonly found in traditional herbal medicines and modern research for its potential therapeutic applications.

What are the main uses of Neferine (CAS: 2292-16-2)?

Neferine is primarily used in pharmaceutical research for its neuroprotective and anti-inflammatory effects. It has applications in the treatment of neurodegenerative diseases, such as Alzheimer's, and is also studied for its role in cardiovascular health. Additionally, Neferine is used in the food industry as a natural antioxidant and in cosmetic formulations for skin care benefits.

Is Neferine (CAS: 2292-16-2) safe?

Neferine is generally considered safe when used in appropriate concentrations and under proper guidance. However, it should be handled with care, as high doses may cause toxicity. Safety standards recommend following established guidelines for its use in medicinal and industrial applications to ensure minimal risk to human health and the environment.

How should Neferine (CAS: 2292-16-2) be stored?

Neferine should be stored in a cool, dry place away from direct sunlight. It is best kept in a sealed container at a temperature below 25°C and with low humidity. Proper storage ensures its stability and prevents degradation, maintaining its efficacy and safety for use in research and pharmaceutical applications.