Fosamprenavir Calcium

Basic Information

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CAS Number

226700-81-8

Molecular Formula

C25H34CaN3O9PS

Molecular Weight

623.7 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Agricultural Chemicals Pesticides Insecticides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Melting Point

282-2840C

SMILES

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CC(C)CN(CC(C(CC1=CC=CC=C1)NC(=O)OC2CCOC2)OP(=O)([O-])[O-])S(=O)(=O)C3=CC=C(C=C3)N.[Ca+2]

InChI

InChI=1S/C25H36N3O9PS.Ca/c1-18(2)15-28(39(33,34)22-10-8-20(26)9-11-22)16-24(37-38(30,31)32)23(14-19-6-4-3-5-7-19)27-25(29)36-21-12-13-35-17-21;/h3-11,18,21,23-24H,12-17,26H2,1-2H3,(H,27,29)(H2,30,31,32);/q;+2/p-2/t21-,23-,24+;/m0./s1

InChIKey

PMDQGYMGQKTCSX-HQROKSDRSA-L

LogP

5.44910

Complexity

901

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H332 Harmful if inhaled
Acute toxicity, inhalation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

PMDQGYMGQKTCSX-HQROKSDRSA-L
GW-433908G
FOSAMPRENAVIR CALCIUM (MART.)
CAS-226700-81-8
C74170
EX-A6824A
FOSAMPRENAVIR CALCIUM [EMA EPAR]
Telzir
226700-81-8
AMY6787
Fosamprenavir calcium, >=98% (HPLC)
DTXCID8026777
Fosamprenavir calcium
Lexiva (TN)
Calcium (2R,3S)-1-(4-amino-N-isobutylphenylsulfonamido)-4-phenyl-3-(((((S)-tetrahydrofuran-3-yl)oxy)carbonyl)amino)butan-2-yl phosphate
Amprenavir phosphate calcium
(3S)-TETRAHYDRO-3-FURYL ((alphaS)-alpha-((1R)-1-HYDROXY-2-(N1-ISOBUTYLSULFANILAMIDO)ETHYL)PHENETHYL)CARBAMATE, CALCIUM PHOSPHATE (ESTER) (1:1)
HY-17431
FOSAMPRENAVIR CALCIUM [ORANGE BOOK]
Tox21_112632
UNII-ID1GU2627N
FOSAMPRENAVIR CALCIUM [MART.]
FOSAMPRENAVIR CALCIUM SALT [MI]
SMR004703563
FOSAMPRENAVIR CALCIUM [WHO-DD]
((3S)Oxolan-3-yloxy)-N-((1S,2R)-3-(((4-aminophenyl)sulfonyl)(2-methylpropyl)amino)-1-benzyl-2-(phosphonooxy)propyl)carboxamide calcium salt
GW433908G
ID1GU2627N
AKOS015950832
NCGC00168771-01
Lexiva

MDL Number

MFCD08141843

FAQ

What is Fosamprenavir Calcium (CAS: 226700-81-8)?

Fosamprenavir Calcium is a prodrug used in the treatment of HIV infection. It is a salt of fosamprenavir and calcium, intended for oral administration. The chemical formula is C36H43CaN4O6S. It is a white or off-white powder with a bitter taste.

What are the main uses of Fosamprenavir Calcium (CAS: 226700-81-8)?

Fosamprenavir Calcium is primarily used in combination with other antiretroviral drugs to treat HIV-1 infection in adults and pediatric patients. It works by inhibiting the viral protease, a crucial enzyme in the replication of the virus.

Is Fosamprenavir Calcium (CAS: 226700-81-8) safe?

Fosamprenavir Calcium is generally considered safe when used as directed. However, it can cause side effects such as diarrhea, nausea, and elevated liver enzymes. It is important to follow the prescribed dosage and monitor for any adverse reactions.

How should Fosamprenavir Calcium (CAS: 226700-81-8) be stored?

Fosamprenavir Calcium should be stored at room temperature, between 15°C and 30°C (59°F and 86°F). It should be kept in a tightly closed container to protect it from moisture and light. Do not expose it to extreme temperatures or direct sunlight.