N-[(1R)-1-(1-Naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]-1-propanamine

Basic Information

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CAS Number

226256-56-0

Molecular Formula

C22H22F3N

Molecular Weight

357.42 g/mol

Chemical Classification

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Boiling Point

440.9 ºC at 760mmHg

Density

1.154

Flash Point

220.5 ºC

Refractive Index

1.563

SMILES

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CC(C1=CC=CC2=CC=CC=C21)NCCCC3=CC(=CC=C3)C(F)(F)F

InChI

InChI=1S/C22H22F3N/c1-16(20-13-5-10-18-9-2-3-12-21(18)20)26-14-6-8-17-7-4-11-19(15-17)22(23,24)25/h2-5,7,9-13,15-16,26H,6,8,14H2,1H3/t16-/m1/s1

InChIKey

VDHAWDNDOKGFTD-MRXNPFEDSA-N

LogP

6.142000000000005

Topological Polar Surface Area

12.03 Å²

Hydrogen Bond Donor/Acceptor

1 / 1

Complexity

422

Synonyms & References

English

(R)-N-(3-(3-trifluoromethylphenyl)propyl)-1-(1-naphthyl)ethylamine
AC-8974
UNII-UAZ6V7728S
AMG073
DTXCID3028261
(R)-N-(1-(Naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine
N-((1R)-1-(Naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine
1025064-29-2
CINACALCET [USAN]
1-Naphthalenemethanamine, alpha-methyl-N-(3-(3-(trifluoromethyl)phenyl)propyl)-, (alphaR)-
s5191
AKOS015909821
AB01274759_02
N-((1R)-1-(1-Naphthyl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine
KRN1493
BDBM50416875
CINACALCET [EMA EPAR]
CHEMBL1201284
BS-16242
Cinacalcet [USAN:INN:BAN]
Q193978
HSDB 7318
Cinacalcet
H05BX01
N-[(1R)-1-(1-naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine
N-[(1r)-1-(naphthalen-1-yl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine
CHEBI:48390
N-[(1R)-1-naphthalen-1-ylethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine
[(1R)-1-(naphthalen-1-yl)ethyl]({3-[3-(trifluoromethyl)phenyl]propyl})amine
NCGC00181002-01
CINACALCET [HSDB]

MDL Number

MFCD09840270

Customs Code

2921499090

FAQ

What are the physical and chemical properties of N-[(1R)-1-(1-naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]-1-propanamine (CAS: 226256-56-0)?

N-[(1R)-1-(1-naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]-1-propanamine is a crystalline compound with a molecular weight of approximately 486.42 g/mol. It has a low solubility in water but is more soluble in organic solvents like dichloromethane and acetonitrile. The compound shows moderate reactivity towards nucleophiles and electrophiles, making it suitable for various organic reactions. It is stable under normal storage conditions but should be protected from moisture and extreme temperatures.

How is N-[(1R)-1-(1-naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]-1-propanamine (CAS: 226256-56-0) typically synthesized?

N-[(1R)-1-(1-naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]-1-propanamine is synthesized through a multistep process involving reactions such as alkylation and amide formation. The synthesis typically requires the use of appropriate catalysts and protecting groups. The overall yield is around 75-80%, and the selectivity is generally good, with high purity achieved through column chromatography and recrystallization.

What industries use N-[(1R)-1-(1-naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]-1-propanamine (CAS: 226256-56-0)?

N-[(1R)-1-(1-naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]-1-propanamine finds application in the pharmaceutical industry for its potential use as a pharmaceutical intermediate. It is also used in the development of sensors and in the semiconductor industry for its unique electronic properties. The compound’s ability to form stable complexes with metals makes it valuable in polymers for improving their mechanical and thermal stability.

What precautions should be taken when handling N-[(1R)-1-(1-naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]-1-propanamine (CAS: 226256-56-0)?

When handling N-[(1R)-1-(1-naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]-1-propanamine, it is essential to use personal protective equipment (PPE) such as gloves, goggles, and lab coats. The compound should be stored in a fume hood and away from sources of ignition and oxidizing agents. In case of a spill, it should be cleaned up using absorbent materials and disposed of according to local regulations. Safety data sheets (SDS) should be consulted for detailed handling and emergency procedures.