4-[(2S)-4-Acryloyl-2-methyl-1-piperazinyl]-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methyl-3-pyridinyl)pyrido[2,3-d]pyrimidin-2(1H)-one

Basic Information

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CAS Number

2252403-56-6

Molecular Formula

C30H30F2N6O3

Molecular Weight

560.61 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Boiling Point

730.5±70.0 °C(Predicted)

Density

1.36±0.1 g/cm3(Predicted)

Solubility

DMSO:75.0(Max Conc. mg/mL);133.78(Max Conc. mM)Water:33.33(Max Conc. mg/mL);59.45(Max Conc. mM)Ethanol:8.0(Max Conc. mg/mL);14.27(Max Conc. mM)

SMILES

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C=CC(=O)N1CCN(C(C1)C)c1nc(=O)n(c2c1cc(F)c(n2)c1c(O)cccc1F)c1c(C)ccnc1C(C)C

InChI

InChI=1S/C30H30F2N6O3/c1-6-23(40)36-12-13-37(18(5)15-36)28-19-14-21(32)26(24-20(31)8-7-9-22(24)39)34-29(19)38(30(41)35-28)27-17(4)10-11-33-25(27)16(2)3/h6-11,14,16,18,39H,1,12-13,15H2,2-5H3/t18-/m0/s1

InChIKey

NXQKSXLFSAEQCZ-SFHVURJKSA-N

LogP

4.481420000000004

pKa

6.52±0.35(Predicted)

Topological Polar Surface Area

104.45000000000002 Å²

Hydrogen Bond Donor/Acceptor

1 / 9

Complexity

1030

Synonyms & References

English

6-FLUORO-7-(2-FLUORO-6-HYDROXYPHENYL)-1-[4-METHYL-2-(PROPAN-2-YL)PYRIDIN-3-YL]-4-[(2S)-2-METHYL-4-(P
6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(propan-2-yl)pyridin-3-yl]-4-[(2S)-2-methyl-4-(prop-2-enoyl)piperazin-1-yl]-1H,2H-pyrido[2,3-d]pyrimidin-2-one
AMG-510
AMG 510
AMG510
4-((S)-4-acryloyl-2-methylpiperazin-1-yl)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-d]pyrimidin-2(1H)-one
chiral AMG 510, single isomer
CPD2809
AMG-510，AMG510
6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(4-methyl-2-propan-2-ylpyridin-3-yl)-4-[(2S)-2-methyl-4-prop-2-enoylpiperazin-1-yl]pyrido[2,3-d]pyrimidin-2-one
AMG510 racemate
Kras G12C inhibitor 9
2B2VM6UC8G
GTPL10678
BCP30452
BCP33368
s8830
DB15569
4-((S)-4-Acryloyl-2-methylpiperazin-1-yl)
CID 137278711
Sotorasib racemate

MDL Number

MFCD32062763

FAQ

What is 4-[(2S)-4-Acryloyl-2-methyl-1-piperazinyl]-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methyl-3-pyridinyl)pyrido[2,3-d]pyrimidin-2(1H)-one (CAS: 2252403-56-6)?

4-[(2S)-4-Acryloyl-2-methyl-1-piperazinyl]-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methyl-3-pyridinyl)pyrido[2,3-d]pyrimidin-2(1H)-one is a complex organic compound with a CAS number of 2252403-56-6. It features a pyrido[2,3-d]pyrimidinone skeleton with fluorine substituents and a piperazinyl acryloyl group, making it a versatile intermediate in chemical synthesis.

What are the main uses of 4-[(2S)-4-Acryloyl-2-methyl-1-piperazinyl]-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methyl-3-pyridinyl)pyrido[2,3-d]pyrimidin-2(1H)-one (CAS: 2252403-56-6)?

4-[(2S)-4-Acryloyl-2-methyl-1-piperazinyl]-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methyl-3-pyridinyl)pyrido[2,3-d]pyrimidin-2(1H)-one is primarily used as a precursor in the synthesis of pharmaceuticals and other organic compounds due to its unique molecular structure.

Is 4-[(2S)-4-Acryloyl-2-methyl-1-piperazinyl]-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methyl-3-pyridinyl)pyrido[2,3-d]pyrimidin-2(1H)-one (CAS: 2252403-56-6) safe?

4-[(2S)-4-Acryloyl-2-methyl-1-piperazinyl]-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methyl-3-pyridinyl)pyrido[2,3-d]pyrimidin-2(1H)-one is generally safe when handled with appropriate precautions. However, it is important to follow safety guidelines, wear protective clothing, and ensure proper ventilation during synthesis and storage to avoid potential hazards.

How should 4-[(2S)-4-Acryloyl-2-methyl-1-piperazinyl]-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methyl-3-pyridinyl)pyrido[2,3-d]pyrimidin-2(1H)-one (CAS: 2252403-56-6) be stored?

4-[(2S)-4-Acryloyl-2-methyl-1-piperazinyl]-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methyl-3-pyridinyl)pyrido[2,3-d]pyrimidin-2(1H)-one should be stored in a cool, dry environment away from direct sunlight and moisture. It is best to keep it in a tightly sealed container to prevent degradation and ensure safety during transport and storage.