2-Fluoro-4-iodopyridine

Basic Information

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CAS Number

22282-70-8

Molecular Formula

C5H3FIN

Molecular Weight

222.99 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Physical State

Yellow to Brown Solid

Melting Point

56.0 to 60.0 deg-C

Boiling Point

223°C at 760 mmHg

Refractive Index

1.6

SMILES

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C1=CN=C(C=C1I)F

InChI

InChI=1S/C5H3FIN/c6-5-3-4(7)1-2-8-5/h1-3H

InChIKey

ADPRIAVYIGHFSO-UHFFFAOYSA-N

LogP

1.8252999999999997

Topological Polar Surface Area

12.89 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Complexity

78.8

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Sensitiveness

Light Sensitive

Synonyms & References

English

A4789
PS-7808
4-Iodo-2-fluoropyridine
AC-4556
SY009117
SCHEMBL256099
PB12274
F0773
BCP01627
DTXSID80427514
2-Fluoro-4-iodopyridine, AldrichCPR
2-Fluoro-4-iodopyridine
W-206745
FT-0645663
22282-70-8
AKOS005145717
2-fluoro-4-iodo-pyridine
ZB1367
Pyridine, 2-fluoro-4-iodo-
ADPRIAVYIGHFSO-UHFFFAOYSA-N
fluoro-4-iodo pyridine
CS-B0944
EN300-136975
MFCD03092926
AM20050963
C5H3FIN
2-floro-4-iodopyridine
2-fluoro-4-iodopyridine

MDL Number

MFCD03092926

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 2-Fluoro-4-iodopyridine (CAS: 22282-70-8)?

2-Fluoro-4-iodopyridine has a crystalline form and a molecular weight of approximately 261.01 g/mol. It shows limited solubility in common organic solvents like methanol and ethanol. The compound is moderately reactive towards nucleophiles and electrophiles due to the presence of a fluoro and an iodo substituent.

How is 2-Fluoro-4-iodopyridine (CAS: 22282-70-8) typically synthesized?

2-Fluoro-4-iodopyridine can be synthesized via the reaction of 2-chloro-4-iodopyridine with potassium fluoride in a suitable solvent like dimethylformamide (DMF). The use of a phase transfer catalyst can improve the reaction selectivity and yield. The reaction is typically monitored by TLC or HPLC to ensure the desired product formation.

What industries use 2-Fluoro-4-iodopyridine (CAS: 22282-70-8)?

2-Fluoro-4-iodopyridine is used in the pharmaceutical industry for the synthesis of intermediates. It may also find applications in the polymer industry for developing new materials with specific properties. Additionally, it could be used in the sensor and semiconductor industries for specific reactivity and electronic properties.

What precautions should be taken when handling 2-Fluoro-4-iodopyridine (CAS: 22282-70-8)?

When handling 2-Fluoro-4-iodopyridine, it is important to wear appropriate personal protective equipment such as gloves, safety glasses, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize exposure. Spills should be cleaned up using appropriate absorbent materials, and the area should be well-ventilated. Always refer to the Safety Data Sheet (SDS) for detailed handling and emergency procedures.