Methyl 3-bromo-2-(bromomethyl)propanoate

Basic Information

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CAS Number

22262-60-8

Molecular Formula

C5H8Br2O2

Molecular Weight

259.92 g/mol

Basic Physical Properties

Boiling Point

62°C/0.4mmHg

Refractive Index

n20/D 1.508(lit.)

SMILES

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COC(=O)C(CBr)CBr

InChI

InChI=1S/C5H8Br2O2/c1-9-5(8)4(2-6)3-7/h4H,2-3H2,1H3

InChIKey

USXVPPOARMSYGY-UHFFFAOYSA-N

LogP

1.5654

Topological Polar Surface Area

26.3 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Complexity

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Synonyms & References

English

AKOS009157094
EN300-61326
PMID27977313-Compound-46
NCI60_005942
A4781
NSC-620109
M2066
Methyl Bis(bromomethyl)acetate
3-Bromo-2-bromomethyl-propionic acid methyl ester
Methyl 3-bromo-2-(bromomethyl)propionate, 98%
Methyl 3-bromo-2-(bromomethyl)propanoate
MFCD00011534
22262-60-8
CHEMBL1974159
3-bromo-2-(bromomethyl)-propionic acid methyl ester
AS-38076
NSC620109
Propanoic acid, 3-bromo-2-(bromomethyl)-, methyl ester
Methyl beta,beta'-Dibromoisobutyrate
DTXSID00176810
NS00027114
3-Bromo-2-(bromomethyl)propionic Acid Methyl Ester
J-014613
Methyl 3-bromo-2-(bromomethyl)propionate
CS-0112200
METHYL 2-BIS-(BROMOMETHYL)-ACETATE
Methyl 3-bromo-2-(bromomethyl)propanoate #
SCHEMBL329106
FT-0638206
SY028615
Methyl 3-Bromo-2-(bromomethyl)propionate

MDL Number

MFCD00011534

Customs Code

2915900090

FAQ

What are the physical and chemical properties of Methyl 3-bromo-2-(bromomethyl)propanoate (CAS: 22262-60-8)?

Methyl 3-bromo-2-(bromomethyl)propanoate (CAS: 22262-60-8) is a colorless or white crystalline solid with a molecular weight of approximately 322.93 g/mol. It has a low solubility in water but is soluble in organic solvents such as ethanol and acetone. Chemically, it is highly reactive due to the presence of two bromine atoms, making it useful in various chemical syntheses.

How is Methyl 3-bromo-2-(bromomethyl)propanoate (CAS: 22262-60-8) typically synthesized?

Methyl 3-bromo-2-(bromomethyl)propanoate (CAS: 22262-60-8) can be synthesized through the bromination of methyl 2-(bromomethyl)propanoate using bromine in the presence of a Lewis acid catalyst like iron(III) bromide. The reaction is typically carried out in a non-polar solvent to ensure good solubility of the reactants and products, with high selectivity and yield.

What industries use Methyl 3-bromo-2-(bromomethyl)propanoate (CAS: 22262-60-8)?

Methyl 3-bromo-2-(bromomethyl)propanoate (CAS: 22262-60-8) is primarily used in the pharmaceutical and polymer industries for the synthesis of various organic compounds. It serves as a valuable intermediate in the development of new drugs and materials, particularly in areas requiring highly functionalized molecules.

What precautions should be taken when handling Methyl 3-bromo-2-(bromomethyl)propanoate (CAS: 22262-60-8)?

When handling Methyl 3-bromo-2-(bromomethyl)propanoate (CAS: 22262-60-8), it is essential to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a laboratory coat. The compound should be handled in a well-ventilated area or a fume hood due to its volatility and reactivity. In case of a spill, it should be immediately cleaned up using appropriate absorbent materials, and the area should be thoroughly ventilated. Refer to the Safety Data Sheet (SDS) for more detailed information on safety measures.