Aripiprazole EP Impurity A

Basic Information

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CAS Number

22246-18-0

Molecular Formula

C9H9NO2

Molecular Weight

163.18 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Melting Point

233.0 to 239.0 deg-C

Boiling Point

403.7°C at 760 mmHg

Density

1.2820

Flash Point

198℃

Refractive Index

1.604

SMILES

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C1CC(=O)NC2=C1C=CC(=C2)O

InChI

InChI=1S/C9H9NO2/c11-7-3-1-6-2-4-9(12)10-8(6)5-7/h1,3,5,11H,2,4H2,(H,10,12)

InChIKey

LKLSFDWYIBUGNT-UHFFFAOYSA-N

LogP

1.2769

Topological Polar Surface Area

49.33 Å²

Hydrogen Bond Donor/Acceptor

2 / 3

Complexity

193

Safety Information

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GHS Hazard Pictograms

H302

H317

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H317 May cause an allergic skin reaction
Sensitization, Skin

Synonyms & References

English

3,4-Dihydro-7-hydroxy-2(1H)-quinoline
AC-7028
CCG-266302
A816050
DTXSID70382941
7-Hydroxy-3,4-dihydrocarbostyril
EN300-155560
8HJ
BDBM50493470
AB25068
FD18013
MFCD06410891
2(1H)-QUINOLINONE, 3,4-DIHYDRO-7-HYDROXY-
VFU6XCR3Q3
CHEMBL2430711
7-hydroxy-3,4-dihydro-carbostyril
AKOS005622540
CS-W010846
GF-0122
FT-0601230
3,4-DIHYDRO-7-HYDROXYQUINOLIN-2(1H)-ONE
7-hydroxy-3,4-dihydro-quinolin-2(1H)-one
UNII-VFU6XCR3Q3
3,4-Dihydro-7-hydroxycarbostyril
7-(hydroxyl)-3,4-dihydroquinolin-2(1h)-one
7-hydroxy-1,2,3,4-tetrahydroquinolin-2-one
HY-W010130
7-Hydroxy-3,4-dihydroquinolin-2(1H)-one;7-Hydroxy-3,4-dihydro carbostyril;7-Hydroxy-3,4-dihydro-2(1H)-quinolinone;7-Hydroxy-2-oxo-1,2,3,4-tetrahydroquinoline;
BCP27862
AKOS005551353
AM20060553

MDL Number

MFCD06410891

FAQ

What is Aripiprazole EP Impurity A (CAS: 22246-18-0)?

Aripiprazole EP Impurity A, with the CAS number 22246-18-0, is a chemical compound that serves as an impurity in the production of aripiprazole, an atypical antipsychotic medication. It is typically identified as 3-(2,3-Dihydro-1H-inden-1-yl)-1-(4-fluorophenyl)-1H-pyrrolo[3,4-b]pyridine. This compound is known for its structural similarity to aripiprazole and is often analyzed to ensure product purity and safety in pharmaceutical manufacturing.

What are the main uses of Aripiprazole EP Impurity A (CAS: 22246-18-0)?

Aripiprazole EP Impurity A is primarily used in pharmaceutical quality control to detect and quantify impurities in aripiprazole drug substances. It may also be relevant in research for studying the synthesis pathways, degradation products, and potential side effects of the parent compound. Its presence is monitored to meet regulatory standards and ensure the safety and efficacy of the final medication.

Is Aripiprazole EP Impurity A (CAS: 22246-18-0) safe?

Aripiprazole EP Impurity A is generally considered safe when handled in accordance with standard laboratory and industrial safety protocols. However, as with any chemical, appropriate protective measures such as gloves, goggles, and ventilation should be used. Safety data sheets (SDS) should be consulted for specific handling instructions, and exposure limits should be followed to minimize health risks.

How should Aripiprazole EP Impurity A (CAS: 22246-18-0) be stored?

Aripiprazole EP Impurity A should be stored in a cool, dry, and well-ventilated area, away from light and moisture. It is typically kept in a sealed container at a temperature range of 15–25°C. Proper storage conditions are essential to maintain its chemical stability and prevent degradation or contamination.