Apalutamide Impurity 43

Basic Information

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CAS Number

22245-83-6

Molecular Formula

C6H4F3NO

Molecular Weight

163.1 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Physical State

Pale-yellow to Yellow-brown Solid

Melting Point

153.0 to 157.0 deg-C

Boiling Point

223.7°C at 760 mmHg

Density

1.398

Flash Point

89.1℃

Refractive Index

1.436

SMILES

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C1=CNC(=O)C(=C1)C(F)(F)F

InChI

InChI=1S/C6H4F3NO/c7-6(8,9)4-2-1-3-10-5(4)11/h1-3H,(H,10,11)

InChIKey

JHDCDEHVUADNKQ-UHFFFAOYSA-N

LogP

1.8059999999999996

Topological Polar Surface Area

33.120000000000005 Å²

Hydrogen Bond Donor/Acceptor

1 / 2

Complexity

239

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Hazard Class

Class 6.1 Class 6.1

Synonyms & References

English

2-hydroxy-3-trifluoromethyl-pyridine
3-(Trifluoromethyl)pyridin-2(1H)-one
2-Hydroxy-3-Trifluoromethyl Pyridine
HTF (SSRE-021)
SCHEMBL908781
3-(Trifluoromethyl)pyridin-2-ol, 3-(Trifluoromethyl)pyridin-2(1H)-one
EN300-28545
3-trifluoromethyl-pyridin-2-ol
3-(TRIFLUOROMETHYL)-2(1H)-PYRIDINONE
DS-0797
2-hydroxy-3-(trifluoromethyl)-pyridine
3-(Trifluoromethyl)-2-pyridone
A4777
3-(Trifluoromethyl)-2-pyridinone
3-(TRIFLUOROMETHYL)-1,2-DIHYDROPYRIDIN-2-ONE
Maybridge1_006338
SY012473
MFCD00153194
AKOS001434019
AB04092
FD2043
3-(trifluoromethyl)pyridin-2-ol
FT-0600957
FS-1128
2-Hydroxy-3-(trifluoromethyl)pyridine
3-trifluoromethyl-pyridone
CS-W002444
BCP22483
AKOS028108750
Z235348047
3-(trifluoromethyl)-1H-pyridin-2-one

MDL Number

MFCD00153194

Customs Code

2933399090

FAQ

What is Apalutamide Impurity 43 (CAS: 22245-83-6)?

Apalutamide Impurity 43 (CAS: 22245-83-6) is a synthetic compound identified as an impurity in the pharmaceutical drug Apalutamide. It is a white to off-white crystalline solid with limited solubility in water and moderate solubility in organic solvents. Its molecular structure and exact chemical formula are not publicly disclosed, but it is characterized as a byproduct of Apalutamide synthesis, requiring careful analysis for quality control purposes.

What are the main uses of Apalutamide Impurity 43 (CAS: 22245-83-6)?

Apalutamide Impurity 43 (CAS: 22245-83-6) is primarily used in pharmaceutical research and quality control to identify and quantify impurities in Apalutamide production. It may also serve as a reference standard in analytical methods such as HPLC or GC for ensuring drug purity. Its applications are limited to laboratory settings and do not extend to industrial, food, or consumer use.

Is Apalutamide Impurity 43 (CAS: 22245-83-6) safe?

Apalutamide Impurity 43 (CAS: 22245-83-6) is not intended for human or animal use and is classified as a chemical impurity. Safety data is limited, but standard laboratory precautions apply, including use of personal protective equipment (PPE) and avoiding inhalation or skin contact. It should be handled in accordance with chemical safety regulations to minimize exposure risks.

How should Apalutamide Impurity 43 (CAS: 22245-83-6) be stored?

Apalutamide Impurity 43 (CAS: 22245-83-6) should be stored in a cool, dry place (ideally below 25°C), protected from light, and in a sealed, airtight container to maintain stability. It is recommended to store in a well-ventilated area and keep away from incompatible materials to prevent degradation or contamination.