Tigecycline | CAS No. 220620-09-7

Tigecycline

Basic Information

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CAS Number

220620-09-7

Molecular Formula

C29H39N5O8

Molecular Weight

585.66 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ketones

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Melting Point

163-173°C

Boiling Point

890.922°C at 760 mmHg

Density

1.455g/cm3

Flash Point

492.612°C

SMILES

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CC(C)(C)NCC(=O)NC1=CC(=C2CC3CC4C(C(=O)C(=C(C4(C(=O)C3=C(C2=C1O)O)O)O)C(=O)N)N(C)C)N(C)C

InChI

InChI=1S/C29H39N5O8/c1-28(2,3)31-11-17(35)32-15-10-16(33(4)5)13-8-12-9-14-21(34(6)7)24(38)20(27(30)41)26(40)29(14,42)25(39)18(12)23(37)19(13)22(15)36/h10,12,14,21,31,36,38-39,42H,8-9,11H2,1-7H3,(H2,30,41)(H,32,35)/t12-,14-,21-,29-/m0/s1

InChIKey

FPZLLRFZJZRHSY-HJYUBDRYSA-N

LogP

0.5132000000000024

Topological Polar Surface Area

205.76000000000002 Å²

Hydrogen Bond Donor/Acceptor

8 / 13

Complexity

1240

Safety Information

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Hazard Statement

H318 Causes serious eye damage
Serious eye damage/eye irritation

H360 May damage fertility or the unborn child
Reproductive toxicity

H410 Very toxic to aquatic life with long lasting effects
Hazardous to the aquatic environment, long-term hazard

Hazard Class

Class 9 Class 9

Synonyms & References

English

SOVUOXKZCCAWOJ-HJYUBDRYSA-N
NS00011897
220620-09-7 (anhy.)
Tigecycline
Tigecycline hydrate
(4s,4as,5ar,12as)-9-(2-t-butylaminoacetylamino)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydronaphthacene-2-carboxamide
CAS-220620-09-7
Tigecycline [USAN]
NSC794945
CHEBI:149836
2-Naphthacenecarboxamide, 4,7-bis(dimethylamino)-9-[[2-[(1,1-dimethylethyl)amino]acetyl]amino]-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-, (4S,4aS,5aR,12aS)-
DTXSID2048581
HMS3714I13
Q420595
(4s,4as,5ar,12as)-9-[2-(tert-butylamino)acetamido]-4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide
WAY-GAR-936
TIGECYCLINE [EP MONOGRAPH]
AKOS025401452
GAR936
D01079
DB00560
TIGECYCLINE [WHO-DD]
HSDB 8172
BCPP000045
AS-30703
Tigecycline 95%
2-Naphthacenecarboxamide, 4,7-bis(dimethylamino)-9-((2-((1,1-dimethylethyl)amino)acetyl)amino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-, (4S,4aS,5aR,12aS)-
(4S,4aS,5aR,12aS)-9-(2-(tert-Butylamino)acetamido)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1
(4S,4aS,5aR,12aS)-9-[(N-tert-butylglycyl)amino]-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
TIGECYCLINE [ORANGE BOOK]
(4S,4aS,5aR,12aS)-4,7-Bis(dimethylamino)-9-[[2-[(1,1-dimethylethyl)amino]acetyl]amino]-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide; Tygacil; WAY-GAR 936; Glycylcycline;

MDL Number

MFCD00935753

FAQ

What is Tigecycline (CAS: 220620-09-7)?

Tigecycline is a glycylcycline antibiotic, a derivative of tetracycline, used primarily for treating severe bacterial infections. Its chemical formula is C22H23ClN2O4S, and it exhibits good stability in aqueous solutions. It is known for its broad-spectrum activity against both Gram-positive and Gram-negative bacteria, including some multidrug-resistant strains.

What are the main uses of Tigecycline (CAS: 220620-09-7)?

Tigecycline is mainly used in pharmaceuticals to treat complicated skin and soft tissue infections, as well as intra-abdominal infections. It is also applied in research for studying antibiotic resistance mechanisms. Due to its broad-spectrum activity, it serves as an alternative for patients with allergies to other tetracycline antibiotics.

Is Tigecycline (CAS: 220620-09-7) safe?

Tigecycline is generally considered safe when used as directed, but it should be handled with care to avoid skin irritation and inhalation risks. Safety standards require proper protective equipment during handling. It is important to follow medical guidelines to prevent misuse and potential development of antibiotic resistance.

How should Tigecycline (CAS: 220620-09-7) be stored?

Tigecycline should be stored in a cool, dry place away from direct light. It is typically kept at a temperature between 15°C to 25°C (59°F to 77°F) and should be protected from moisture. Storage in airtight containers is recommended to maintain its stability and efficacy over time.