Hydroxyzine dihydrochloride

Basic Information

View in Editor

CAS Number

2192-20-3

Molecular Formula

C21H29Cl3N2O2

Molecular Weight

447.83 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Melting Point

190-192°C

Boiling Point

499.2°C at 760 mmHg

Density

1.182

Flash Point

9℃

Solubility

H2O: soluble

SMILES

View in Editor

C1CN(CCN1CCOCCO)C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl.Cl.Cl

InChI

InChI=1S/C21H27ClN2O2.2ClH/c22-20-8-6-19(7-9-20)21(18-4-2-1-3-5-18)24-12-10-23(11-13-24)14-16-26-17-15-25;;/h1-9,21,25H,10-17H2;2*1H

InChIKey

ANOMHKZSQFYSBR-UHFFFAOYSA-N

LogP

3.8995000000000046

Topological Polar Surface Area

35.940000000000005 Å²

Hydrogen Bond Donor/Acceptor

1 / 4

Complexity

376

Safety Information

View Safety Information

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Toxicity

LD50 in rats (mg/kg): 126 i.p.; 950 orally (Goldenthal)

Synonyms & References

English

MFCD00058200
Ethanol, 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-, dihydrochloride, (-)-
Ataraxoid dihydrochloride
Hydroxyzine Hcl
Hydroxyzine Hydrochloride 1.0 mg/ml in Methanol (as free base)
Hydroxyzine hydrochloride (JP17/USP)
Ethanol, 2-(2-(4-(p-chloro-alpha-phenylbenzyl)-1-piperazinyl)ethoxy)-, dihydrochloride
Hydroxyzine dihydrochloride
Prestwick_272
HS-0097
Hydroxyzine-d4 2HCl
Disron
ANOMHKZSQFYSBR-UHFFFAOYSA-N
AC-8086
C21H29Cl3N2O2
163837-37-4
SR-01000003137
Ethanol, 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-, dihydrochloride
CHEMBL3186993
Hydroxyzine Dihydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material
Hydroxyzine dihydrochloride, (-)-
2-(2-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)ethanol 2HCl
Tran-Q dihydrochloride
Hydroxyzine.2HCl
Atarax dihydrochloride
2192-20-3 (2HCl)
HYDROXYZINE HYDROCHLORIDE [VANDF]
HYDROXYZINE HYDROCHLORIDE [WHO-DD]
Q27106898
Dichlorhydrate de 1-p.chlorbenzhydryl-4-(2-(2-hydroxyethoxy)ethyl)piperazine [French]
2192-20-3

MDL Number

MFCD00058200

Customs Code

2933990090

FAQ

What is Hydroxyzine dihydrochloride (CAS: 2192-20-3)?

Hydroxyzine dihydrochloride (CAS: 2192-20-3) is a hydrochloride salt of hydroxyzine, an antihistaminic compound with the molecular formula C17H25NO2·2HCl. It appears as a white crystalline powder and is soluble in water. Known for its sedative and antiemetic properties, it is commonly used in pharmaceutical formulations to treat allergic reactions, anxiety, and pruritus.

What are the main uses of Hydroxyzine dihydrochloride (CAS: 2192-20-3)?

Hydroxyzine dihydrochloride (CAS: 2192-20-3) is primarily used as an antihistamine in pharmaceuticals for managing allergies, urticaria, and anxiety-related symptoms. It also serves as an antiemetic to alleviate nausea and vomiting. In research settings, it is employed to study histamine receptor interactions and as a tool for pharmacological investigations.

Is Hydroxyzine dihydrochloride (CAS: 2192-20-3) safe?

Hydroxyzine dihydrochloride (CAS: 2192-20-3) is considered safe when used as directed, with a low toxicity profile. However, it should be handled with care to avoid eye or skin contact, and ingestion should be avoided. Safety standards recommend following OSHA guidelines for proper storage and disposal to ensure minimal risk to humans and the environment.

How should Hydroxyzine dihydrochloride (CAS: 2192-20-3) be stored?

Hydroxyzine dihydrochloride (CAS: 2192-20-3) should be stored in a cool, dry place, preferably at 20-25°C, in a tightly sealed container to prevent moisture ingress. Protection from light is essential to maintain its stability and potency. Avoid exposure to high temperatures or humidity to prevent degradation.