(2R,6S)-2,6-dimethylpiperazine

Basic Information

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CAS Number

21655-48-1

Molecular Formula

C6H14N2

Molecular Weight

114.19 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Melting Point

112.0 to 115.0 deg-C

Boiling Point

160°C

Flash Point

113 °F

Refractive Index

1.4628 (estimate)

SMILES

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CC1CNCC(N1)C

InChI

InChI=1S/C6H14N2/c1-5-3-7-4-6(2)8-5/h5-8H,3-4H2,1-2H3/t5-,6+

InChIKey

IFNWESYYDINUHV-OLQVQODUSA-N

LogP

-0.043800000000000006

Topological Polar Surface Area

24.06 Å²

Hydrogen Bond Donor/Acceptor

2 / 2

Complexity

64.9

Safety Information

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Hazard Statement

H228 Flammable solid
Flammable solids

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Hazard Class

Class 4.1 Class 4.1

Sensitiveness

Light Sensitive & Hygroscopic

Synonyms & References

English

(cis)-2,6-dimethylpiperazine
(2S,6R)-2,6-dimethylpiperazine
AKOS006350052
cis-2,6-dimethyl-piperazin
PS-5344
cis-3,5 dimethyl piperazine
DTXSID301296263
(cis)-2,6-dimethyl-piperazine
1013625-96-1
2,6 cis-dimethyl piperazine
21655-48-1
(2r,6s)-rel-2,6-dimethylpiperazine
(cis)2,6-dimethylpiperazine
(cis)-3,5-Dimethylpiperazine
(2S,6R)-2,6-dimethyl-piperazine
AC-19708
Z1203730758
2,6-cis-dimethylpiperazine
cis 2,6-dimethylpiperazine
cis-3,5-dimethylpiperazine
cis-3,5-dimethyl piperazine
2,6-Dimethylpiperazine #
(2R,65)-2,6-Dimethylpiperazine
(2R,6S) 2,6-Dimethyl-piperazine
CIS-2,6-DIMETHYL-PIPERAZINE
AM81381
(2R,6S)-2,6-Dimethyl-piperazine
MFCD07772435
D2360
Piperazine, 2,6-dimethyl-, cis-
P10485

MDL Number

MFCD07772435

Customs Code

2933599090

FAQ

What regulatory guidelines apply to (2R,6S)-2,6-dimethylpiperazine (CAS: 21655-48-1)?

(2R,6S)-2,6-dimethylpiperazine is regulated under the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) for its health and environmental hazards. In the European Union, it falls under the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) regulation. Additionally, the U.S. Food and Drug Administration (FDA) and Environmental Protection Agency (EPA) have guidelines for its handling and use, including proper storage and disposal to prevent environmental contamination.

Are there alternatives to (2R,6S)-2,6-dimethylpiperazine in synthesis?

Yes, alternatives include various piperazine analogs such as (2R)-2-methylpiperazine and (2S,6S)-2,6-dimethylpiperazine. Isomers such as (2S,6R)-2,6-dimethylpiperazine can also be used. Common alternative reagents in synthesis include diisopropylethylamine and triethylamine. These alternatives can provide similar functionality with different properties, allowing for flexibility in chemical processes.

What is the market or research trend for (2R,6S)-2,6-dimethylpiperazine?

The market for (2R,6S)-2,6-dimethylpiperazine is driven by its use in pharmaceuticals, agrochemicals, and as a precursor in organic synthesis. Research trends are focusing on its application in drug discovery and development, particularly in the treatment of neurological disorders and as a potential herbicide ingredient. Market trends show increasing demand due to its utility in various industries and ongoing research efforts.

How should waste containing (2R,6S)-2,6-dimethylpiperazine be handled?

Waste containing (2R,6S)-2,6-dimethylpiperazine should be collected in appropriate containers and stored under sealed conditions to prevent leaks. It should be disposed of through professional waste disposal services to ensure proper incineration or other environmentally safe methods. In the event of a spill, immediate containment is necessary, followed by professional cleanup to avoid environmental contamination. All disposal activities must comply with local, national, and international regulations for hazardous waste management.