Morpholine,4-[3-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-1-oxo-2-propenyl]-

Basic Information

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CAS Number

211867-47-9

Molecular Formula

C21H22FNO4

Molecular Weight

371.4 g/mol

Basic Physical Properties

Boiling Point

556.3°C at 760 mmHg

Flash Point

290.3°C

Refractive Index

1.565

SMILES

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COC1=C(C=C(C=C1)C(=CC(=O)N2CCOCC2)C3=CC=C(C=C3)F)OC

InChI

InChI=1S/C21H22FNO4/c1-25-19-8-5-16(13-20(19)26-2)18(15-3-6-17(22)7-4-15)14-21(24)23-9-11-27-12-10-23/h3-8,13-14H,9-12H2,1-2H3/b18-14+

InChIKey

BKBSMMUEEAWFRX-NBVRZTHBSA-N

LogP

3.1334000000000017

Topological Polar Surface Area

48.0 Å²

Hydrogen Bond Donor/Acceptor

0 / 5

Complexity

512

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

SCHEMBL1389289
Flumorph
3-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-1-morpholin-4-ylprop-2-en-1-one
CID 20056423
(E)-flumorph
CHEBI:83430
CCRIS 9057
SYP-L190
CHEBI:83428
HY-17521
UNII-AV4LX5WS5P
3-(3,4-Dimethoxyphenyl)-3-(4-fluorophenyl)-1-morpholinoprop-2-en-1-one
211867-47-9
Morpholine,4-[3-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-1-oxo-2-propenyl]-
4-(3-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-1-oxo-2-propenyl)morpholine
AMY3300
CS-3307
Flumorph 100 microg/mL in Acetonitrile
(2E)-3-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-1-(morpholin-4-yl)prop-2-en-1-one
Q19279669
A879211
3-(4-chlorophenyl)-3-(3,4-dimethoxyphenyl)-1-(morpholin-4-yl)prop-2-en-1-one
AS-79577
SYP-L190SYP-L190
(E)-3-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-1-morpholin-4-ylprop-2-en-1-one
AV4LX5WS5P
Flumorph [ISO]
4-[3-(3,4-Dimethoxyphenyl)-3-(4-fluorophenyl)-1-oxo-2-propenyl]morpholine
Flumorph Solution
(EZ)-4-[3-(3,4-Dimethoxyphenyl)-3-(4-fluorophenyl)acryloyl]morpholine

MDL Number

MFCD08690411

FAQ

What are the physical and chemical properties of Morpholine,4-[3-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-1-oxo-2-propenyl] (CAS: 211867-47-9)?

Morpholine,4-[3-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-1-oxo-2-propenyl] (CAS: 211867-47-9) has a crystalline form with a molecular weight of approximately 424.4 g/mol. It is soluble in common organic solvents such as ethanol and acetone but has limited aqueous solubility. This compound exhibits moderate reactivity, particularly towards nucleophilic substitution and acid/base reactions.

How is Morpholine,4-[3-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-1-oxo-2-propenyl] (CAS: 211867-47-9) typically synthesized?

Morpholine,4-[3-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-1-oxo-2-propenyl] (CAS: 211867-47-9) is typically synthesized through a multistep process involving the condensation of a fluoroacetophenone derivative with a dimethoxyphenol, followed by ring-closing metathesis and further purification steps. Common catalysts include Grubbs catalysts, with high selectivity and yield.

What industries use Morpholine,4-[3-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-1-oxo-2-propenyl] (CAS: 211867-47-9)?

Morpholine,4-[3-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-1-oxo-2-propenyl] (CAS: 211867-47-9) finds applications in pharmaceuticals for its potential use as a precursor in drug synthesis. It is also utilized in the polymer industry for the development of advanced materials. Additionally, it has potential applications in sensor technology and semiconductor manufacturing due to its unique chemical properties.

What precautions should be taken when handling Morpholine,4-[3-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-1-oxo-2-propenyl] (CAS: 211867-47-9)?

When handling Morpholine,4-[3-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-1-oxo-2-propenyl] (CAS: 211867-47-9), it is essential to wear personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should always be conducted in a well-ventilated area or a fume hood. Spills should be cleaned up immediately using appropriate absorbents, and the material safety data sheet (MSDS) should be consulted for detailed handling instructions.