14-{[2-(2,6-Dioxo-3-piperidinyl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}-3,6,9,12-tetraoxatetradecan-1-oic acid

Basic Information

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CAS Number

2097938-44-6

Molecular Formula

C23H29N3O10

Molecular Weight

507.5 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

SMILES

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OC(=O)COCCOCCOCCOCCNc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c21

InChI

InChI=1S/C23H29N3O10/c27-18-5-4-17(21(30)25-18)26-22(31)15-2-1-3-16(20(15)23(26)32)24-6-7-33-8-9-34-10-11-35-12-13-36-14-19(28)29/h1-3,17,24H,4-14H2,(H,28,29)(H,25,27,30)

InChIKey

ZXAUDUQJSKVKNG-UHFFFAOYSA-N

LogP

-0.34929999999999545

Topological Polar Surface Area

169.8 Å²

Hydrogen Bond Donor/Acceptor

3 / 13

Complexity

807

Synonyms & References

English

E3 Ligase Ligand-Linker Conjugates 1
Pomalidomide-PEG4-C-COOH
2-[2-[2-[2-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]acetic acid
BCP31562
AT11901
A936455
Cereblon Ligand -Linker Conjugates 1;Pomalidomide-PEG4-C-COOH

MDL Number

MFCD31540390

FAQ

What are the physical and chemical properties of 14-{[2-(2,6-Dioxo-3-piperidinyl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}-3,6,9,12-tetraoxatetradecan-1-oic acid (CAS: 2097938-44-6)?

14-{[2-(2,6-Dioxo-3-piperidinyl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}-3,6,9,12-tetraoxatetradecan-1-oic acid is a white to off-white crystalline solid. Its molecular weight is approximately 454.43 g/mol. The compound is sparingly soluble in water but soluble in organic solvents. It is reactive towards bases and exhibits good stability under neutral conditions.

How is 14-{[2-(2,6-Dioxo-3-piperidinyl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}-3,6,9,12-tetraoxatetradecan-1-oic acid (CAS: 2097938-44-6) typically synthesized?

14-{[2-(2,6-Dioxo-3-piperidinyl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}-3,6,9,12-tetraoxatetradecan-1-oic acid can be synthesized through multi-step reactions involving condensation reactions and ring formations. Commonly, it is synthesized by reacting 14-amino-tetradecanoic acid with 2-(2,6-dioxo-3-piperidinyl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl chloride using a suitable organic base like triethylamine and a phase transfer catalyst. The overall yield is around 75-80%, and the purity is typically >95%.

What industries use 14-{[2-(2,6-Dioxo-3-piperidinyl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}-3,6,9,12-tetraoxatetradecan-1-oic acid (CAS: 2097938-44-6)?

14-{[2-(2,6-Dioxo-3-piperidinyl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}-3,6,9,12-tetraoxatetradecan-1-oic acid is primarily used in the pharmaceutical industry for its potential as an active pharmaceutical ingredient (API) in certain drugs. It may also have applications in the polymer industry, where it can be used as a stabilizer or functional additive.

What precautions should be taken when handling 14-{[2-(2,6-Dioxo-3-piperidinyl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}-3,6,9,12-tetraoxatetradecan-1-oic acid (CAS: 2097938-44-6)?

When handling 14-{[2-(2,6-Dioxo-3-piperidinyl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}-3,6,9,12-tetraoxatetradecan-1-oic acid, use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. It should be stored in a dry place, away from heat and direct sunlight. Handle in a well-ventilated area or a fume hood to avoid inhalation of dust. In case of a spill, immediately clean up using appropriate absorbents and dispose of according to local regulations. Refer to the safety data sheet (SDS) for detailed information.