DAPT | CAS No. 208255-80-5

DAPT

Basic Information

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CAS Number

208255-80-5

Molecular Formula

C23H26F2N2O4

Molecular Weight

432.47 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Boiling Point

612.2°C at 760 mmHg

Solubility

DMSO: ~18 mg/mL

SMILES

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CC(C(=O)NC(C1=CC=CC=C1)C(=O)OC(C)(C)C)NC(=O)CC2=CC(=CC(=C2)F)F

InChI

InChI=1S/C23H26F2N2O4/c1-14(26-19(28)12-15-10-17(24)13-18(25)11-15)21(29)27-20(16-8-6-5-7-9-16)22(30)31-23(2,3)4/h5-11,13-14,20H,12H2,1-4H3,(H,26,28)(H,27,29)/t14-,20?/m0/s1

InChIKey

DWJXYEABWRJFSP-PVCZSOGJSA-N

LogP

3.2112000000000007

Topological Polar Surface Area

84.50000000000001 Å²

Hydrogen Bond Donor/Acceptor

2 / 6

Complexity

622

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Sensitiveness

Light Sensitive

Synonyms & References

English

n-(n-(3,5-difluorophenacetyl)-l-alanyl)-s-phenylglycine tert-butyl ester
tert-butyl (2S)-({N-[(3,5-difluorophenyl)acetyl]-L-alanyl}amino)(phenyl)acetate
AC-23163
tert-butyl (S)-2-((S)-2-(2-(3,5-difluorophenyl)acetamido)propanamido)-2-phenylacetate
CCG-264944
(3,5-Difluorophenylacetyl)-L-alanyl-L-2-phenylglycine tert-Butyl Ester
gamma-Secretase Inhibitor IX
GTPL11363
LY-374973
J-013656
J-524356
Q27158972
t-butyl (2s)-2-[[(2s)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoyl]amino]-2-phenylacetate
AS-19399
DAPT (GMP)
HY-13027G
DAPT,GSI-IX
HB3345
DWJXYEABWRJFSP-XOBRGWDASA-N
N-{N-[2-(3,5-Difluorophenyl)acetyl]-(S)-alanyl}- (S)-phenylglycine tert-butyl ester
Gamma-Secretase Inhibitor IX;N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-butyl ester
CS-0264
N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine tbutyl ester
D4257
Glycine, N-[2-(3,5-difluorophenyl)acetyl]-L-alanyl-2-phenyl-, 1,1-dimethylethyl ester, (2S)-
DAPT (GSI-IX)
MRF-0000012
HMS3413L17
N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-Butyl Ester
TB2634-GMP
DAPT (peptide)

MDL Number

MFCD04974585

Customs Code

2924299090

FAQ

What is DAPT (CAS: 208255-80-5)?

DAPT, also known as DL-4-(2-Amino-2-(cyclohexylmethyl)vinyl)-3-methyl-2-pyrrolidinone, is a G protein-coupled receptor (GPCR) modulator with specific antagonistic activity at the NMDA receptor NR2B subunit. It is commonly used in research to study neural plasticity and is also used in drug discovery for its pharmacological properties.

What are the main uses of DAPT (CAS: 208255-80-5)?

DAPT is primarily used in research to investigate the mechanisms of neuron signaling and plasticity. It is also utilized in drug discovery to develop treatments for neurodegenerative diseases and pain management. Its specific antagonistic activity at the NMDA receptor NR2B subunit makes it a valuable tool in these fields.

Is DAPT (CAS: 208255-80-5) safe?

DAPT is generally considered safe when handled properly. However, it is important to follow all safety guidelines, including wearing appropriate personal protective equipment (PPE) such as gloves and goggles, and working in a well-ventilated area. Avoid contact with skin and eyes, and ensure proper disposal of waste materials.

How should DAPT (CAS: 208255-80-5) be stored?

DAPT should be stored in a cool, dry place, away from direct sunlight and heat sources. It should be kept in a tightly sealed container to prevent exposure to air and moisture. Store it at room temperature (15-25°C) and protect from light. Avoid freezing and keep away from flammable materials.