2-Methyl 1-(2-methyl-2-propanyl) (2S)-4,4-difluoro-1,2-pyrrolidinedicarboxylate | CAS No. 203866-17-5

2-Methyl 1-(2-methyl-2-propanyl) (2S)-4,4-difluoro-1,2-pyrrolidinedicarboxylate

Basic Information

CAS Number

203866-17-5

Molecular Formula

C11H17F2NO4

Molecular Weight

265.26 g/mol

AD

Basic Physical Properties

Melting Point

41-46 °C

Boiling Point

293 ºC

Refractive Index

1.455

CC(C)(C)OC(=O)N1CC(CC1C(=O)OC)(F)F

InChI

InChI=1S/C11H17F2NO4/c1-10(2,3)18-9(16)14-6-11(12,13)5-7(14)8(15)17-4/h7H,5-6H2,1-4H3/t7-/m0/s1

InChIKey

RQDZKOOUQIDZOG-ZETCQYMHSA-N

LogP

1.8041

Topological Polar Surface Area

55.84 Ų

Hydrogen Bond Donor/Acceptor

0 / 5

Complexity

351

Synonyms & References

English

  • N-BOC-4,4-DIFLUORO-L-PROLINE METHYL ESTER
  • DS-16679
  • BCP21719
  • MFCD03094918
  • 1-tert-butyl 2-methyl(2s)-4,4-difluoropyrrolidine-1,2-dicarboxylate
  • METHYL (S)-1-BOC-4,4-DIFLUOROPYRROLIDINE-2-CARBOXYLATE
  • 1,2-Pyrrolidinedicarboxylicacid,4,4-difluoro-,1-(1,1-dimethylethyl)2-methyl ester,(2S)-
  • SCHEMBL706243
  • N-Boc-4,4-Difluoro-L-proline methyl ester, 97%
  • J-013267
  • (S)-1-tert-butyl 2-methyl 4,4-difluoropyrrolidine-1,2-dicarboxylate
  • 203866-17-5
  • (S)-4,4-Difluoro-N-Boc-pyrrolidine-2-carboxylic acid methyl ester
  • CHEMBL4924940
  • CS-W001497
  • (S)-4,4-difluoro-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester
  • AMY3074
  • 1-(tert-butyl) 2-methyl (S)-4,4-difluoropyrrolidine-1,2-dicarboxylate
  • 1,2-Pyrrolidinedicarboxylic acid, 4,4-difluoro-, 1-(1,1-dimethylethyl) 2-methyl ester, (2S)-
  • AKOS015920188
  • TERT-BUTYL (2S)-2-(METHOXYCARBONYL)-4,4-DIFLUOROPYRROLIDINE-1-CARBOXYLATE
  • BOC-4,4-DIFLUORO-L-PROLINE METHYL ESTER
  • A850871
  • DTXSID90456299
  • (S)-1-tert-butyl 2-methyl 4,4-difluoropyrrolidine-1,2-dicarboxylate;N-Boc-4,4-difluoro-L-proline Methyl Ester
  • Methyl (2S)-N-(tert-butyloxycarbonyl)-4,4-difluoropyrrolidine-2-carboxylate
  • 1-O-tert-butyl 2-O-methyl (2S)-4,4-difluoropyrrolidine-1,2-dicarboxylate
  • 1-tert-butyl 2-methyl (2S)-4,4-difluoropyrrolidine-1,2-dicarboxylate
  • (S)-1-tert-Butyl 2-methyl 4,4-difluoropyrrolidine-1,2-dicarboxylate
  • N-Boc-4,4-difluoro-L-proline methyl ester
  • BOC-44-DIFLUORO-L-PROLINE METHYL ESTER

MDL Number

MFCD03094918

Customs Code

2933990090

FAQ

What are the physical and chemical properties of 2-Methyl 1-(2-methyl-2-propanyl) (2S)-4,4-difluoro-1,2-pyrrolidinedicarboxylate (CAS: 203866-17-5)?

2-Methyl 1-(2-methyl-2-propanyl) (2S)-4,4-difluoro-1,2-pyrrolidinedicarboxylate (CAS: 203866-17-5) is a white crystalline solid with a molecular weight of approximately 314.05 g/mol. It has a low solubility in water and organic solvents. The compound is moderately reactive, especially in acidic conditions. It is stable under normal conditions but should be stored away from strong acids and bases.

How is 2-Methyl 1-(2-methyl-2-propanyl) (2S)-4,4-difluoro-1,2-pyrrolidinedicarboxylate (CAS: 203866-17-5) typically synthesized?

2-Methyl 1-(2-methyl-2-propanyl) (2S)-4,4-difluoro-1,2-pyrrolidinedicarboxylate (CAS: 203866-17-5) is typically synthesized through a multi-step process involving the formation of 1,4-difluoropyrrolidine, followed by esterification with the corresponding acetic anhydride derivative. The reaction involves the use of a mild acid catalyst and proceeds with high selectivity and good yield.

What industries use 2-Methyl 1-(2-methyl-2-propanyl) (2S)-4,4-difluoro-1,2-pyrrolidinedicarboxylate (CAS: 203866-17-5)?

2-Methyl 1-(2-methyl-2-propanyl) (2S)-4,4-difluoro-1,2-pyrrolidinedicarboxylate (CAS: 203866-17-5) is used in various industries, including pharmaceuticals for the synthesis of certain drugs, polymers for the development of advanced materials, and as a precursor in the semiconductor industry for the production of electronic components. Its applications also extend to the preparation of sensor materials and other specialized chemical intermediates.

What precautions should be taken when handling 2-Methyl 1-(2-methyl-2-propanyl) (2S)-4,4-difluoro-1,2-pyrrolidinedicarboxylate (CAS: 203866-17-5)?

When handling 2-Methyl 1-(2-methyl-2-propanyl) (2S)-4,4-difluoro-1,2-pyrrolidinedicarboxylate (CAS: 203866-17-5), it is essential to use appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. The compound should be stored in a cool, dry place, away from heat sources and direct sunlight. In case of a spill, it should be handled in a well-ventilated area and cleaned up using appropriate safety protocols. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions.

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