1-(beta-D-Ribofuranosyl)-2-thioxo-2,3-dihydro-4(1H)-pyrimidinone | CAS No. 20235-78-3

1-(beta-D-Ribofuranosyl)-2-thioxo-2,3-dihydro-4(1H)-pyrimidinone

Basic Information

CAS Number

20235-78-3

Molecular Formula

C9H12N2O5S

Molecular Weight

260.27 g/mol

AD

Basic Physical Properties

Melting Point

214-215 ºC

C1=CN(C(=S)NC1=O)C2C(C(C(O2)CO)O)O

InChI

InChI=1S/C9H12N2O5S/c12-3-4-6(14)7(15)8(16-4)11-2-1-5(13)10-9(11)17/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,17)/t4-,6-,7-,8-/m1/s1

InChIKey

GJTBSTBJLVYKAU-XVFCMESISA-N

LogP

-1.48261

Topological Polar Surface Area

107.71000000000001 Ų

Hydrogen Bond Donor/Acceptor

4 / 7

Complexity

374

Synonyms & References

English

  • 2-thiouridine
  • 1-beta-D-ribofuranosyl-2-thiouracil
  • 1-((2S,3S,4R,5S)-3,4-dihydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one;s2U; AC1MI168, CHEBI:60731
  • s2U
  • AS-10679
  • CS-0068136
  • 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one
  • GJTBSTBJLVYKAU-XVFCMESISA-N
  • CHEBI:60731
  • 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-4-hydroxy-pyrimidine-2-thione
  • 1-(beta-D-ribofuranosyl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one
  • 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-2-thioxo-pyrimidin-4-one
  • 3sfg
  • 2TU
  • 20235-78-3
  • 1-((2S,3S,4R,5S)-3,4-dihydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one?s2U; AC1MI168, CHEBI:60731
  • Uridine, 2-thio-
  • A848688
  • F12662
  • MFCD03788697
  • Q20890502
  • 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-sulfanylidenepyrimidin-4-one
  • BP-58834
  • DTXSID90174087
  • SCHEMBL41558
  • AKOS025149643
  • PD053638
  • beta-D-ribofuranosyl-2-thiouridine
  • AM84694
  • 2-Thiouridine
  • 1-beta-D-Ribofuranosyl-2-thiouracil

MDL Number

MFCD03788697

FAQ

What regulatory guidelines apply to 1-(beta-D-Ribofuranosyl)-2-thioxo-2,3-dihydro-4(1H)-pyrimidinone (CAS: 20235-78-3)?

This compound is regulated under the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) as a category 1A mutagen. It is also subject to the European Union’s REACH regulations, which require registration for substances above certain tonnage thresholds. FDA and EPA may also have specific labeling and handling requirements for this compound, particularly in pharmaceutical and environmental contexts.

Are there alternatives to 1-(beta-D-Ribofuranosyl)-2-thioxo-2,3-dihydro-4(1H)-pyrimidinone (CAS: 20235-78-3) in synthesis?

Several alternatives can be used in the synthesis of this compound, such as 1-(beta-D-Ribofuranosyl)-2-thiohydantoin, which serves as a similar structural analog. Common alternative reagents include 2-thiouracil and other pyrimidine derivatives.

What is the market or research trend for 1-(beta-D-Ribofuranosyl)-2-thioxo-2,3-dihydro-4(1H)-pyrimidinone (CAS: 20235-78-3)?

Research trends indicate increasing interest in this compound due to its potential use as a mutagenic agent in genetic studies. Market trends highlight a growing demand in pharmaceutical and biotech industries for mutagenic compounds to study DNA repair mechanisms and enzyme interactions.

How should waste containing 1-(beta-D-Ribofuranosyl)-2-thioxo-2,3-dihydro-4(1H)-pyrimidinone (CAS: 20235-78-3) be handled?

Waste containing this compound should be collected in appropriate containers and disposed of through professional waste disposal services, as it is a regulated mutagen. Incineration is recommended for safe disposal, provided it meets environmental and safety standards. Proper environmental protection precautions, such as adequate ventilation and protective equipment, must be observed during handling and disposal.

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