N-[(Benzyloxy)carbonyl]-L-leucine

Basic Information

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CAS Number

2018-66-8

Molecular Formula

C14H19NO4

Molecular Weight

265.31 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Boiling Point

442.8℃ at 760 mmHg

Water Solubility

Not miscible or difficult to mix in water. Soluble in chloroform, DMSO and methanol.

Refractive Index

n20/D 1.512(lit.)

Specific Rotation

-17 º (c=2, ethanol)

SMILES

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CC(C)CC(C(=O)O)NC(=O)OCC1=CC=CC=C1

InChI

InChI=1S/C14H19NO4/c1-10(2)8-12(13(16)17)15-14(18)19-9-11-6-4-3-5-7-11/h3-7,10,12H,8-9H2,1-2H3,(H,15,18)(H,16,17)/t12-/m0/s1

InChIKey

USPFMEKVPDBMCG-LBPRGKRZSA-N

LogP

2.4120999999999997

Topological Polar Surface Area

75.63 Å²

Hydrogen Bond Donor/Acceptor

2 / 5

Complexity

298

Safety Information

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GHS Hazard Pictograms

H226

H351

Hazard Statement

H226 Flammable liquid and vapor
Flammable liquids

H351 Suspected of causing cancer
Carcinogenicity

Hazard Class

Class 3 Class 3

Synonyms & References

English

N-(Carbobenzoxy)leucine
EINECS 217-960-3
HY-Y0555
Z-Leu
Carbobenzoxy-L-leucine
(Carbobenzoxy)leucine
n-[(benzyloxy)carbonyl]-l-leucine
Cbz-Leu
N-Benzyloxycarbonylleucine
AM81876
N-(Benzyloxycarbonyl)-L-leucine
Z-Leu-OH, 97%
Q27103608
FS-4054
Nalpha -benzyloxycarbonyl-L-leucine
N-benzoxycarbonyl-L-leucine
P48HHX9XNP
EN300-121296
(Benzyloxycarbonyl)leucine
N-Benzyloxycarbonyl-L-leucine
DTXSID80174011
cbz-leu-oh
(s)-2-(benzyloxycarbonylamino)-4-methylpentanoic acid
N-((Phenylmethoxy)carbonyl)-L-leucine
(2S)-4-methyl-2-(phenylmethoxycarbonylamino)pentanoic acid
(2S)-2-(Benzyloxycarbonylamino)-4-methylpentanoic acid
L-N-(Benzyloxycarbonyl)leucine
3-06-00-01503 (Beilstein Handbook Reference)
SCHEMBL222158
((Benzyloxy)carbonyl)-L-leucine
L-Leucine, N-((phenylmethoxy)carbonyl)-

MDL Number

MFCD00026494

Customs Code

2924299090

FAQ

What is N-[(Benzyloxy)carbonyl]-L-leucine (CAS: 2018-66-8)?

N-[(Benzyloxy)carbonyl]-L-leucine (CAS: 2018-66-8) is a protected amino acid derivative commonly used in peptide synthesis. Its chemical formula is C16H19NO5, and it appears as a white crystalline solid. The compound features a benzyloxy carbonyl (Z) group attached to the amino acid leucine, enhancing its stability during chemical reactions. It is a key intermediate in organic chemistry and pharmaceutical research.

What are the main uses of N-[(Benzyloxy)carbonyl]-L-leucine (CAS: 2018-66-8)?

N-[(Benzyloxy)carbonyl]-L-leucine (CAS: 2018-66-8) is primarily used in pharmaceuticals for synthesizing peptides and proteins. It serves as a building block in drug development, particularly in creating bioactive molecules. Additionally, it is utilized in research for studying amino acid functionality and in industrial applications for chemical derivatization. Its protected form allows controlled release of leucine in complex reactions.

Is N-[(Benzyloxy)carbonyl]-L-leucine (CAS: 2018-66-8) safe?

N-[(Benzyloxy)carbonyl]-L-leucine (CAS: 2018-66-8) is generally considered safe when handled properly. However, it requires standard laboratory precautions, such as wearing gloves and safety goggles, to avoid skin or eye contact. While not classified as highly toxic, inhalation of powder should be minimized. Always follow safety guidelines for chemical handling to ensure workplace safety.

How should N-[(Benzyloxy)carbonyl]-L-leucine (CAS: 2018-66-8) be stored?

N-[(Benzyloxy)carbonyl]-L-leucine (CAS: 2018-66-8) should be stored in a cool, dry place (2-8°C) in airtight containers to prevent moisture exposure. It is sensitive to light, so storage in darkness is recommended. Avoid humid environments to maintain stability, and use glass or sealed plastic containers to protect from air and contaminants. Proper storage ensures prolonged shelf life and prevents degradation.