6-Chloro-9-(beta-D-ribofuranosyl)-9H-purin-2-amine

Basic Information

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CAS Number

2004-07-1

Molecular Formula

C10H12ClN5O4

Molecular Weight

301.69 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Physical State

Powder

Melting Point

175°C

Boiling Point

729.9°C at 760 mmHg

Flash Point

395.2±35.7 °C

Solubility

DMSO, Methanol

Refractive Index

-38 ° (C=0.1, H2O)

Specific Rotation

-34 - -40° (c=0.1, H2O)

SMILES

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C1=NC2=C(N1C3C(C(C(O3)CO)O)O)N=C(N=C2Cl)N

InChI

InChI=1S/C10H12ClN5O4/c11-7-4-8(15-10(12)14-7)16(2-13-4)9-6(19)5(18)3(1-17)20-9/h2-3,5-6,9,17-19H,1H2,(H2,12,14,15)/t3-,5-,6-,9-/m1/s1

InChIKey

TXWHPSZYRUHEGT-UUOKFMHZSA-N

LogP

-1.3266000000000007

Topological Polar Surface Area

139.54000000000002 Å²

Hydrogen Bond Donor/Acceptor

5 / 9

Complexity

367

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H332 Harmful if inhaled
Acute toxicity, inhalation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

6-Chloro-9-beta-D-ribofuranosyl-9H-purin-2-amine
2-Amino-6-chloropurine ribosid
(2R,3R,4S,5R)-2-(2-amino-6-chloropurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
GS-3225
(-)-2-Amino-6-chloropurine riboside
6-Chloro-9-(Beta-D-Ribofuranosyl)-9h-Purin-2-Amine
(3S,2R,4R,5R)-5-(2-amino-6-chloropurin-9-yl)-2-(hydroxymethyl)oxolane-3,4-diol
AKOS015854915
2-Amino-6-chloropurine riboside (6-Chloroguanosine)
EINECS 217-905-3
EN300-1704270
6-Chloroguanosine
NSC 44586
CHEMBL244169
6-chloro-2-amino-9-(beta-D-ribofuranosyl)purine
6-Chloroguanineriboside
Q27456329
2004-07-1
AKOS015896934
6CR
(2R,3R,4S,5R)-2-(2-amino-6-chloro-9H-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
2-Amino-6-chloro-9-(beta-D-ribofuranosyl)purine
2-Amino-6-chloropurine riboside
(4S,2R,3R,5R)-2-[2-amino-6-chloro-purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
2-Amino-6-chloropurine-9-?-D-riboside
TXWHPSZYRUHEGT-UUOKFMHZSA-N
SCHEMBL637420
NS00045737
6-Chloroguanine riboside
2-Amino-6-chloropurine-9-riboside
MFCD00005735

MDL Number

MFCD00005735

Customs Code

29349990

FAQ

What is 6-Chloro-9-(beta-D-ribofuranosyl)-9H-purin-2-amine (CAS: 2004-07-1)?

6-Chloro-9-(beta-D-ribofuranosyl)-9H-purin-2-amine is a purine derivative with a chlorinated pyrimidine ring and a ribose sugar. It is a white to off-white powder with poor solubility in water. This compound is a nucleoside and is closely related to nucleic acids, which are fundamental to genetic information storage and transmission.

What are the main uses of 6-Chloro-9-(beta-D-ribofuranosyl)-9H-purin-2-amine (CAS: 2004-07-1)?

6-Chloro-9-(beta-D-ribofuranosyl)-9H-purin-2-amine is primarily used in pharmaceutical research for developing antiviral and anticancer drugs. It is also utilized in the study of nucleic acid metabolism and as a precursor in the synthesis of nucleoside analogs.

Is 6-Chloro-9-(beta-D-ribofuranosyl)-9H-purin-2-amine (CAS: 2004-07-1) safe?

6-Chloro-9-(beta-D-ribofuranosyl)-9H-purin-2-amine is generally considered safe for laboratory use under controlled conditions. However, it should be handled with care due to its potential irritant properties. Wear gloves, goggles, and protective clothing. Store in a tightly sealed container at room temperature away from direct sunlight. Follow all safety guidelines provided by the Material Safety Data Sheet (MSDS).

How should 6-Chloro-9-(beta-D-ribofuranosyl)-9H-purin-2-amine (CAS: 2004-07-1) be stored?

This compound should be stored in a tightly sealed container at room temperature (15-25°C) away from direct sunlight and heat sources. Keep it in a dry place and avoid exposure to moisture. Store it in a well-ventilated area and ensure that the container is tightly sealed to prevent degradation. Handle with care and use appropriate personal protective equipment when handling.