4-(Methoxymethyl)pyridine

Basic Information

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CAS Number

20027-70-7

Molecular Formula

C7H9NO

Molecular Weight

123.15 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

SMILES

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COCc1ccncc1

InChI

InChI=1S/C7H9NO/c1-9-6-7-2-4-8-5-3-7/h2-5H,6H2,1H3

InChIKey

MBGSSZLPFNHEHX-UHFFFAOYSA-N

LogP

1.228

Topological Polar Surface Area

22.12 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Synonyms & References

English

4-(methoxymethyl)pyridine

MDL Number

MFCD13175366

FAQ

What are the physical and chemical properties of 4-(Methoxymethyl)pyridine (CAS: 20027-70-7)?

4-(Methoxymethyl)pyridine is a white to off-white crystalline solid with a molecular weight of 126.14 g/mol. It is slightly soluble in water but miscible with ethanol and acetone. Chemically, it is less reactive than unsubstituted pyridine but exhibits typical nucleophilic substitution and alkylation reactions. It has a melting point of 58-60°C and a boiling point of 159-161°C.

How is 4-(Methoxymethyl)pyridine (CAS: 20027-70-7) typically synthesized?

4-(Methoxymethyl)pyridine is commonly synthesized via the reaction of 3-chloropyridine with methanol in the presence of a base like sodium hydroxide. This method provides good selectivity and yield. Other methods include the reduction of 4-formylpyridine with methanol using palladium catalysts. These processes yield the desired compound with high purity.

What industries use 4-(Methoxymethyl)pyridine (CAS: 20027-70-7)?

4-(Methoxymethyl)pyridine is used in the pharmaceutical industry for the synthesis of certain drugs, particularly those that require a pyridine-based structure. It is also utilized in the polymer industry for the modification of polymer properties. Additionally, it has applications in sensors and semiconductors due to its electronic properties.

What precautions should be taken when handling 4-(Methoxymethyl)pyridine (CAS: 20027-70-7)?

Handling 4-(Methoxymethyl)pyridine requires the use of appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a fume hood to minimize exposure. Spills should be cleaned up using a suitable absorbent material and proper waste disposal procedures followed. Refer to the Safety Data Sheet (SDS) for detailed information and emergency response procedures.