4-(Methoxymethyl)pyridine(CAS: 20027-70-7)

4-(Methoxymethyl)pyridine is a white to off-white crystalline solid with a molecular weight of 126.14 g/mol. It is slightly soluble in water but miscible with ethanol and acetone. Chemically, it is less reactive than unsubstituted pyridine but exhibits typical nucleophilic substitution and alkylation reactions. It has a melting point of 58-60°C and a boiling point of 159-161°C.

4-(Methoxymethyl)pyridine is commonly synthesized via the reaction of 3-chloropyridine with methanol in the presence of a base like sodium hydroxide. This method provides good selectivity and yield. Other methods include the reduction of 4-formylpyridine with methanol using palladium catalysts. These processes yield the desired compound with high purity.

4-(Methoxymethyl)pyridine is used in the pharmaceutical industry for the synthesis of certain drugs, particularly those that require a pyridine-based structure. It is also utilized in the polymer industry for the modification of polymer properties. Additionally, it has applications in sensors and semiconductors due to its electronic properties.

Handling 4-(Methoxymethyl)pyridine requires the use of appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a fume hood to minimize exposure. Spills should be cleaned up using a suitable absorbent material and proper waste disposal procedures followed. Refer to the Safety Data Sheet (SDS) for detailed information and emergency response procedures.