L-Prolyl-L-leucylglycinamide

Basic Information

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CAS Number

2002-44-0

Molecular Formula

C13H24N4O3

Molecular Weight

284.36 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Water Solubility

Soluble in water.

SMILES

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CC(C)CC(C(=O)NCC(=O)N)NC(=O)C1CCCN1

InChI

InChI=1S/C13H24N4O3/c1-8(2)6-10(12(19)16-7-11(14)18)17-13(20)9-4-3-5-15-9/h8-10,15H,3-7H2,1-2H3,(H2,14,18)(H,16,19)(H,17,20)/t9-,10-/m0/s1

InChIKey

NOOJLZTTWSNHOX-UWVGGRQHSA-N

LogP

-1.1291999999999969

Topological Polar Surface Area

113.32000000000001 Å²

Hydrogen Bond Donor/Acceptor

5 / 7

Complexity

371

Synonyms & References

English

MIF-1
MELANOSTATIN MIF-I
Pro-Leu-Gly-NH2
(2S)-N-(carbamoylmethyl)-4-methyl-2-{[(2S)-pyrrolidin-2-yl]formamido}pentanamide
(S)-Pyrrolidine-2-carboxylic acid [(S)-1-(carbamoylmethyl-carbamoyl)-3-methyl-butyl]-amide
Melanostatin I (ox)
NS-04720
L-pro-L-leu-gly-NH2
MFCD00037866
2002-44-0
CHEBI:168693
(2S)-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]pyrrolidine-2-carboxamide
Oxytocin C-terminal tripeptide
CHEMBL317488
PD070730
NS00026500
3KY24B4Q62
AKOS015955826
6-((E)-3-Oxo-3-phenyl-propenyl)-1H-pyrimidine-2,4-dione
Prolylleucylglycine amide
L-Prolyl-L-leucylglycinamide
BDBM50060601
MFCD08282654
H-Pro-Leu-Gly-NH2
MELANOSTATIN MIF-I [MI]
CS-0029128
(S)-N-((S)-1-((2-Amino-2-oxoethyl)amino)-4-methyl-1-oxopentan-2-yl)pyrrolidine-2-carboxamide
HB1874
DTXSID20173841
MSH RELEASE-INHIBITING FACTOR I
Pro-Leu-Gly amide

MDL Number

MFCD00037866

FAQ

What are the physical and chemical properties of L-Prolyl-L-leucylglycinamide (CAS: 2002-44-0)?

L-Prolyl-L-leucylglycinamide (CAS: 2002-44-0) is a crystalline compound with a molecular weight of approximately 299.38 g/mol. It has a high solubility in water and organic solvents. Chemically, it is relatively stable but can undergo hydrolysis under acidic or basic conditions. Its reactivity is moderate, and it is often used as a model peptide for studying enzyme mechanisms and as a substrate in various biochemical assays.

How is L-Prolyl-L-leucylglycinamide (CAS: 2002-44-0) typically synthesized?

L-Prolyl-L-leucylglycinamide (CAS: 2002-44-0) is typically synthesized via solid-phase peptide synthesis (SPPS) or solution-phase peptide synthesis. The key steps involve the coupling of amino acids, protection/deprotection of the side chains, and cleavage from the solid or liquid support. The yield is often around 70-90%, and the purity is enhanced through HPLC purification.

What industries use L-Prolyl-L-leucylglycinamide (CAS: 2002-44-0)?

L-Prolyl-L-leucylglycinamide (CAS: 2002-44-0) is primarily used in the pharmaceutical and biochemical research industries. It is also utilized in the development of sensor technologies and as a model compound for studying enzyme kinetics and mechanisms. Its applications in semiconductors are less common but emerging due to its unique chemical properties.

What precautions should be taken when handling L-Prolyl-L-leucylglycinamide (CAS: 2002-44-0)?

When handling L-Prolyl-L-leucylglycinamide (CAS: 2002-44-0), it is important to wear protective equipment such as gloves, goggles, and a lab coat. Use a fume hood to minimize exposure to vapors. Spills should be carefully cleaned up using absorbent materials and disposing of the material according to local hazardous waste regulations. Always consult the Safety Data Sheet (SDS) for detailed handling and storage information.