N-(1-((2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxy-3-methoxytetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)acetamide

Basic Information

View in Editor

CAS Number

199593-08-3

Molecular Formula

C33H35N3O8

Molecular Weight

601.66 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Physical State

White to Yellow Solid

Solubility

Insuluble (1.3E-3 g/L) (25 ºC),

SMILES

View in Editor

CC(=O)NC1=NC(=O)N(C=C1)C2C(C(C(O2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)O)OC

InChI

InChI=1S/C33H35N3O8/c1-21(37)34-28-18-19-36(32(39)35-28)31-30(42-4)29(38)27(44-31)20-43-33(22-8-6-5-7-9-22,23-10-14-25(40-2)15-11-23)24-12-16-26(41-3)17-13-24/h5-19,27,29-31,38H,20H2,1-4H3,(H,34,35,37,39)/t27-,29-,30-,31-/m1/s1

InChIKey

FINUHOJILDNELQ-PMFUCWTESA-N

LogP

3.5009000000000015

Topological Polar Surface Area

130.37 Å²

Hydrogen Bond Donor/Acceptor

2 / 11

Complexity

1010

Safety Information

View Safety Information

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H320 Causes eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

N-Acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-cytidine
5'-O-DMT-N4-Acetyl-2'-O-Methyl-cytidine
N-(1-((2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxy-3-methoxytetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)acetamide
N-[1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxy-3-methoxyoxolan-2-yl]-2-oxopyrimidin-4-yl]acetamide
n4-acetyl-5'-(dimethoxytrityl)-2'-o-methylcytidine
N4-ACETYL-5'-O-DMT-2'-O-METHYLCYTIDINE
N-Acetyl-5'-O-[bis(4-methoxyphenyl)-phenylmethyl]-2'-O-methyl-cytidine
N4-acetyl-5'-O-DMTr-2'-O-methylcytidine
N-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methylcytidine
DMT-2'-OMe-Ac-C
5'-DMT-2'-OMe-Ac-C
N4-Acetyl-5'-O-DMT-2'-O-methyl-D-cytidine
N4-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methylcytidine
C33H35N3O8
0261AB
HG1337
5-O-DMT-N4-ACETYL-2-O-ME
5'-O-DMT-N4-ACETYL-2'-O-METHYL-CYTIDINE
SCHEMBL17090823
CS-0172019
N4-Acetyl-5''-O-DMT-2''-O-methylcytidine
Cytidine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-
BS-49486
MFCD08704192
N-{1-[(2R,3R,4R,5R)-5-{[BIS(4-METHOXYPHENYL)(PHENYL)METHOXY]METHYL}-4-HYDROXY-3-METHOXYOXOLAN-2-YL]-2-OXOPYRIMIDIN-4-YL}ACETAMIDE
N4-Acetyl-5'-O-DMT-2'-O-methylcytidine
DTXSID20743381
N4-ACETYL-5'-(DIMETHOXYTRITYL)-2'-O-METHYLCYTIDINE
J-700318
199593-08-3
J-700127

MDL Number

MFCD08704192

FAQ

What are the physical and chemical properties of N-(1-((2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxy-3-methoxytetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)acetamide (CAS: 199593-08-3)?

The compound is a white crystalline solid with a molecular weight of approximately 1000 g/mol. It is sparingly soluble in water but soluble in organic solvents like DMSO and methanol. It exhibits good reactivity towards nucleophiles and can undergo amidation and acylation reactions. The compound is stable under normal conditions but may degrade under strong acid or base conditions.

How is N-(1-((2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxy-3-methoxytetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)acetamide (CAS: 199593-08-3) typically synthesized?

The compound is synthesized using a multistep process involving the protection of hydroxy groups, formation of an acetal, and subsequent amidation. Common synthetic methods include using sodium hydride, triethylamine, and various protecting group strategies. The overall yield is around 60-70%, and the reaction is usually monitored by TLC or HPLC.

What industries use N-(1-((2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxy-3-methoxytetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)acetamide (CAS: 199593-08-3)?

This compound is primarily used in the pharmaceutical industry for its potential as an intermediate in drug synthesis, particularly in the development of antiviral and anti-inflammatory agents. It is also explored for its applications in polymer chemistry and as a component in sensor technologies.

What precautions should be taken when handling N-(1-((2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxy-3-methoxytetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)acetamide (CAS: 199593-08-3)?

Handling this compound requires the use of personal protective equipment (PPE), including gloves, goggles, and a lab coat. It should be stored in a closed container away from moisture and heat. Spills should be handled with caution using appropriate spill kits. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal information.