Compound Q&A

How is N-(1-((2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxy-3-methoxytetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)acetamide (CAS: 199593-08-3) typically synthesized?

Answer

N-(1-((2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxy-3-methoxytetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)acetamide
The compound is synthesized using a multistep process involving the protection of hydroxy groups, formation of an acetal, and subsequent amidation. Common synthetic methods include using sodium hydride, triethylamine, and various protecting group strategies. The overall yield is around 60-70%, and the reaction is usually monitored by TLC or HPLC.

About

English Name N-(1-((2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxy-3-methoxytetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)acetamide
Molecular Formula C33H35N3O8
Molecular Weight 601.6560000000002 g/mol
SMILES CC(=O)NC1=NC(=O)N(C=C1)C2C(C(C(O2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)O)OC
InChIKey FINUHOJILDNELQ-PMFUCWTESA-N
Last Updated: 2025-10-28 10:54

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