(S)-10-Hydroxycamptothecin

Basic Information

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CAS Number

19685-09-7

Molecular Formula

C20H16N2O5

Molecular Weight

364.36 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Physical State

Yellow powder

Melting Point

267°C

Boiling Point

820.7°C at 760 mmHg

Flash Point

450.1±34.3 °C

Solubility

Methanol; DMF

Refractive Index

1.776

SMILES

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CC[C@@]1(O)C(=O)OCc2c1cc3-c4nc5ccc(O)cc5cc4Cn3c2=O

InChI

InChI=1S/C20H16N2O5/c1-2-20(26)14-7-16-17-11(5-10-6-12(23)3-4-15(10)21-17)8-22(16)18(24)13(14)9-27-19(20)25/h3-7,23,26H,2,8-9H2,1H3/t20-/m0/s1

InChIKey

HAWSQZCWOQZXHI-FQEVSTJZSA-N

LogP

1.7851999999999992

Topological Polar Surface Area

101.65 Å²

Hydrogen Bond Donor/Acceptor

2 / 7

Complexity

774

Safety Information

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Hazard Statement

Storage Conditions

-20℃

Synonyms & References

English

(S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
Hydroxy Camptothecine
SN38
CAMPTOTHECIN, 10-HYDROXY-
CAMPTOTHECIN, 10-HYDROXY-, CAMPTOTHECA ACUMINATA
HCPT
HYDROXYCAMPTOTHECIN
HYDROXYCAMPTOTHECIN, 10-
(+/-)-4-ethyl-4,9-dihydroxy-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione
10Hydroxy camptothecin
7-Ethy Hydroxycamptothecin
10-HYDROXYCAMPTOTHECIN
(20S)-7-ETHYL-10-HYDROXYCAMPTOTHECIN
(S)-10-Hydroxycamptothecin
(S)-10-hydroxy-Camptothecin
Camptothecine
Ecdysterone
Hydrocamptothecine
HYDROXYCAMPTOTHECIN, 10-(RG)
10-HCPT
10-Hydroxycamptochecin
10-hydroxycamptothecine
10-hydroxy-CPT
10-OH-camptothecin
Camptothecin,hydroxy
Irinotecan Related Compound A
(S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
(4S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
NSC 107124
[ "" ]
Ampule

MDL Number

MFCD02093100

Customs Code

2934999090

FAQ

What is (S)-10-Hydroxycamptothecin (CAS: 19685-09-7)?

(S)-10-Hydroxycamptothecin is a naturally occurring alkaloid derived from the plant Camptotheca acuminata. It has the chemical formula C20H22N2O6 and is known for its potent antitumor properties. This compound is a derivative of camptothecin and is used in cancer research and drug development due to its ability to inhibit DNA topoisomerase I, which is crucial for DNA replication and repair.

What are the main uses of (S)-10-Hydroxycamptothecin (CAS: 19685-09-7)?

(S)-10-Hydroxycamptothecin is primarily used in pharmaceutical research as a potential anticancer agent. It is also employed in medicinal chemistry for drug design and development. Additionally, it serves as a valuable compound in biochemical studies related to DNA metabolism and enzymatic inhibition. Its unique structure makes it a key player in the development of topoisomerase I inhibitors.

Is (S)-10-Hydroxycamptothecin (CAS: 19685-09-7) safe?

While (S)-10-Hydroxycamptothecin is used in research and pharmaceutical settings, it requires careful handling due to its potential toxicity. It may cause skin irritation, eye damage, and respiratory issues upon exposure. Safety standards recommend using appropriate protective equipment and following standard laboratory safety protocols. Always consult safety data sheets for detailed information.

How should (S)-10-Hydroxycamptothecin (CAS: 19685-09-7) be stored?

(S)-10-Hydroxycamptothecin should be stored in a cool, dry, and dark place, preferably at 2-8°C. It is sensitive to moisture and light, so it should be kept in a tightly sealed container. Storage in a controlled environment helps maintain its chemical stability and potency. Always follow manufacturer guidelines for optimal storage conditions.