1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-azetidinecarboxylic acid

Basic Information

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CAS Number

193693-64-0

Molecular Formula

C19H17NO4

Molecular Weight

323.35 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Melting Point

172.0 to 176.0 deg-C

Boiling Point

543.3°C at 760 mmHg

Flash Point

282°(540°F)

SMILES

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C1C(CN1C(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24)C(=O)O

InChI

InChI=1S/C19H17NO4/c21-18(22)12-9-20(10-12)19(23)24-11-17-15-7-3-1-5-13(15)14-6-2-4-8-16(14)17/h1-8,12,17H,9-11H2,(H,21,22)

InChIKey

QDEJCUHGSHSYQH-UHFFFAOYSA-N

LogP

2.951900000000001

Topological Polar Surface Area

66.84 Å²

Hydrogen Bond Donor/Acceptor

1 / 5

Complexity

480

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H332 Harmful if inhaled
Acute toxicity, inhalation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

1-Fmoc-azetidine-3-carboxylic acid
Fmoc-Azetidine-3-carboxylic acid
1-[(9H-fluoren-9-ylmethoxy)carbonyl]azetidine-3-carboxylic acid
1-(9H-fluoren-9-ylmethoxycarbonyl)azetidine-3-carboxylic Acid
1-(9H-fluoren-9-ylmethoxycarbonyl)azetidine-3-carboxylic acid;1-Fmoc-Azetidine-3-carboxylic acid
AM20050429
SB52173
EN300-624025
ZB0879
HY-W011277
1-{[(9H-FLUOREN-9-YL)METHOXY]CARBONYL}AZETIDINE-3-CARBOXYLIC ACID
F1099
Fmoc-L-Azetidine-3-carboxylic acid
Fmoc-Aze(3)-OH
AKOS015837429
193693-64-0
Indole-3-aldehydeazine
J-012542
FT-0643816
DTXSID60373262
1-(((9H-fluoren-9-yl)methoxy)carbonyl)azetidine-3-carboxylic acid
CS-W011993
SY065299
SCHEMBL119453
A813661
DS-0717
MFCD01321018
QDEJCUHGSHSYQH-UHFFFAOYSA-N
1-Fmoc-azetidine-3-carboxylic acid, >=98.0% (HPLC)
Z1217191433
1-Fmoc-Azetidine-3-carboxylic acid

MDL Number

MFCD01321018

Customs Code

2933990090

FAQ

What regulatory guidelines apply to 1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-azetidinecarboxylic acid (CAS: 193693-64-0)?

The 1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-azetidinecarboxylic acid (CAS: 193693-64-0) is subject to various regulatory guidelines. In the EU, it falls under REACH regulations, requiring manufacturers and importers to register substances of very high concern. For the US market, it complies with FDA and EPA requirements, particularly for environmental protection and safe handling. GHS classification does not apply since the compound is not inherently hazardous under current GHS criteria. Detailed MSDS and SDS are required for safety and regulatory compliance.

Are there alternatives to 1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-azetidinecarboxylic acid (CAS: 193693-64-0) in synthesis?

Several alternatives to 1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-azetidinecarboxylic acid (CAS: 193693-64-0) are available in synthesis. Common analogs include related azetidine derivatives with different substituents, such as fluorenylmethoxycarbonyl (Fmoc) protected derivatives. Alternative reagents like benzyl chloride or other fluorenyl ethers can serve as viable substitutes depending on the specific reaction conditions and desired product profile. However, the choice of alternative depends on the target application and the balance between reactivity and product yield.

What is the market or research trend for 1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-azetidinecarboxylic acid (CAS: 193693-64-0)?

The market for 1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-azetidinecarboxylic acid (CAS: 193693-64-0) shows a steady demand due to its applications in the synthesis of peptides and pharmaceuticals. Research trends indicate increased interest in its use as a protective group in solid-phase peptide synthesis. Despite this, market growth is gradual, with emerging research focusing on the development of more efficient and environmentally friendly synthetic routes. Pricing trends reflect the specialized nature of the compound, with costs influenced by production volume and market demand.

How should waste containing 1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-azetidinecarboxylic acid (CAS: 193693-64-0) be handled?

Waste containing 1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-azetidinecarboxylic acid (CAS: 193693-64-0) should be managed according to local and national regulations. Waste liquid should be collected in appropriate containers and stored under a nitrogen atmosphere to prevent oxidation. For solid waste, it should be packaged in sealed containers and labeled clearly. Incineration is a common disposal method, but professional waste disposal services are recommended for complex compounds. Environmental protection measures include minimizing water usage and ensuring no hazardous substances are released into the environment. Proper disposal and waste management are crucial to comply with regulatory requirements and ensure safety.