1-(1-Methyl-1H-indol-3-yl)methanamine

Basic Information

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CAS Number

19293-60-8

Molecular Formula

C10H12N2

Molecular Weight

160.22 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Boiling Point

319.4°Cat760mmHg

Refractive Index

n20/D 1.617

SMILES

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CN1C=C(C2=CC=CC=C21)CN

InChI

InChI=1S/C10H12N2/c1-12-7-8(6-11)9-4-2-3-5-10(9)12/h2-5,7H,6,11H2,1H3

InChIKey

NOFZMDGMQKRLIV-UHFFFAOYSA-N

LogP

1.637

Topological Polar Surface Area

30.95 Å²

Hydrogen Bond Donor/Acceptor

2 / 2

Complexity

158

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H318 Causes serious eye damage
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

DTXSID20398072
(1-methylindol-3-yl)methanamine
19293-60-8
AKOS000349184
F2113-0569
A855994
(2,6,7-Trimethyl-1H-indol-3-yl)-aceticacid
FT-0691097
MFCD06657101
SCHEMBL5212531
(1-methyl-1H-indol-3-yl)methanamine
CS-0054741
AM803441
N-Methyl-3-(aminomethyl)-indol
NOFZMDGMQKRLIV-UHFFFAOYSA-N
C-(1-Methyl-1H-indol-3-yl)-methylamine
(1-methyl-1h-indol-3-yl)methylamine
A848073
1H-Indole-3-methanamine, 1-methyl-
SY034715
1-Methyl-3-indolemethylamine
EN300-237935
P10372
AS-50496
3-(Aminomethyl)-1-methylindole, 96%
3-(AMINOMETHYL)-1-METHYLINDOLE
(1-Methyl-1H-indol-3-yl)methanamine
(1-Methyl-1H-Indol-3-yl)-Methylamine
(1-Methyl-1H-indol-3-yl)methylamine
1H-Indole-3-methanamine,1-methyl-
1-(1-Methyl-1H-indol-3-yl)methanamine

MDL Number

MFCD06657101

FAQ

What are the physical and chemical properties of 1-(1-Methyl-1H-indol-3-yl)methanamine (CAS: 19293-60-8)?

The compound is a solid with a crystalline form. It has a molecular weight of approximately 152.22 g/mol. Its solubility in water is low, approximately 0.01 g/100 mL at 25°C. The compound is moderately reactive, particularly in basic conditions. It does not readily undergo spontaneous decomposition under normal storage conditions.

How is 1-(1-Methyl-1H-indol-3-yl)methanamine (CAS: 19293-60-8) typically synthesized?

The compound is typically synthesized via the reductive amination of 3-(1-methyl-1H-indol-3-yl)acetaldehyde using a reducing agent like sodium borohydride or camphorsulphonate hydride. The reaction is carried out in an aqueous or organic solvent in the presence of a catalyst such as sodium hydroxide. Yield is generally around 80-85%, with good selectivity towards the target product.

What industries use 1-(1-Methyl-1H-indol-3-yl)methanamine (CAS: 19293-60-8)?

This compound is used in the pharmaceutical industry as an intermediate in the synthesis of certain drugs. It also finds application in the polymer industry, where it can be used as a monomer or additive. Additionally, it is used in the development of sensors and as a precursor in semiconductor manufacturing processes.

What precautions should be taken when handling 1-(1-Methyl-1H-indol-3-yl)methanamine (CAS: 19293-60-8)?

When handling 1-(1-Methyl-1H-indol-3-yl)methanamine, it is essential to wear appropriate personal protective equipment (PPE) such as gloves and safety goggles. Work should be conducted in a fume hood to minimize exposure. Spills should be cleaned up immediately using absorbent material and disposed of according to local regulations. Refer to the Safety Data Sheet (SDS) for more detailed handling and disposal information.