Pomalidomide | CAS No. 19171-19-8

Pomalidomide

Basic Information

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CAS Number

19171-19-8

Molecular Formula

C13H11N3O4

Molecular Weight

273.25 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Melting Point

305-312°C

Boiling Point

582.9°C at 760 mmHg

Flash Point

66.2 °F

Solubility

DMSO: ≥14mg/mL

SMILES

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Nc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c21

InChI

InChI=1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18)

InChIKey

UVSMNLNDYGZFPF-UHFFFAOYSA-N

LogP

-0.33

Topological Polar Surface Area

109.57 Å²

Hydrogen Bond Donor/Acceptor

3 / 7

Complexity

504

Safety Information

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Hazard Statement

H225 Highly Flammable liquid and vapor
Flammable liquids

H302 Harmful if swallowed
Acute toxicity, oral

Synonyms & References

English

4-Amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
3-Amino-N-(2,6-dioxo-3-piperidyl)phthalimide
4-Amino-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione
Pomalidomide
4-amino-2-(2,6-dioxo-3-piperidinyl)-1H-Isoindole-1,3(2H)-dione
Pomalidomide-D4
1H-?Isoindole-?1,?3(2H)?-?dione, 4-?amino-?2-?(2,?6-?dioxo-?3-?piperidinyl)?-
CC4047
CC-4047
1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline
3-amino-N-(2,6-dioxo-3-piperidyl)phthalamide
Actimid
IMiD 3
Actimid (Celgene)
Pomalidomide(CC-4047)
pomalidomide,Pomalyst
Pomalidomide(CC-4047,Actimid)
PoMalyst iMpurity
Pomalyst
Imnovid
4-Aminothalidomide
CC 4047
1H-Isoindole-1,3(2H)-dione, 4-amino-2-(2,6-dioxo-3-piperidinyl)-
IMID-3
AK104087
4-amino-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
4-amino-2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione
4-amino-2-(2,6-dioxo-3-pi
4-Amino-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
ActiMid
Pomalidomide-d4

MDL Number

MFCD12756407

Customs Code

2925190090

FAQ

What is Pomalidomide (CAS: 19171-19-8)?

Pomalidomide is a derivative of thalidomide, with the chemical formula C14H16N2O2. It is a white to off-white crystalline powder, known for its low solubility in water and high solubility in organic solvents. Pomalidomide exhibits immunomodulatory and anti-angiogenic properties, making it a valuable compound in pharmaceutical research.

What are the main uses of Pomalidomide (CAS: 19171-19-8)?

Pomalidomide is primarily used in the treatment of multiple myeloma, particularly in patients who have relapsed or are refractory to other therapies. It is also utilized in research for its potential applications in immunotherapy and as an anti-cancer agent. The compound's unique properties make it relevant in both clinical and experimental settings.

Is Pomalidomide (CAS: 19171-19-8) safe?

Pomalidomide is generally considered safe when used under medical supervision, but it requires careful handling due to potential side effects such as peripheral neuropathy and teratogenicity. Proper safety protocols, including protective clothing and controlled environments, should be followed to minimize risks and ensure compliance with regulatory standards.

How should Pomalidomide (CAS: 19171-19-8) be stored?

Pomalidomide should be stored in a cool, dry, and dark place, ideally at 2-8°C. It is sensitive to moisture and light, so it should be kept in a sealed, light-resistant container. Maintaining proper storage conditions ensures its stability and prolongs its shelf life for both research and pharmaceutical use.