1H-Pyrrolo[2,3-b]pyridin-3-amine

Basic Information

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CAS Number

189882-31-3

Molecular Formula

C7H7N3

Molecular Weight

133.15 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Boiling Point

379.7 °C at 760 mmHg

Flash Point

165℃

Refractive Index

1.78

SMILES

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C1=CC2=C(NC=C2N)N=C1

InChI

InChI=1S/C7H7N3/c8-6-4-10-7-5(6)2-1-3-9-7/h1-4H,8H2,(H,9,10)

InChIKey

HCTKTFWOSSBSIL-UHFFFAOYSA-N

LogP

1.1451000000000002

Topological Polar Surface Area

54.7 Å²

Hydrogen Bond Donor/Acceptor

3 / 3

Complexity

126

Synonyms & References

English

MFCD08272227
AKOS005214187
SB10289
HCTKTFWOSSBSIL-UHFFFAOYSA-N
W-206001
CS-0004100
AMY7162
1H-Pyrrolo[2,3-b]pyridin-3-amine diHCl
1H-Pyrrolo[2,3-b]pyridin-3-ylamine
AS-57243
DTXSID90646552
3-AMINO-7-AZAINDOLE
SCHEMBL5802606
FT-0660073
A813373
A4190
1H-pyrrolo[2,3-b]pyridin-3-amine
EN300-1825987
189882-31-3
1H-Pyrrolo[2,3-b]pyridin-3-amine
3-Amino-7-azaindole
1H-Pyrrolo[2,3-b]pyridin-3-aMine HCl
1H-Pyrrolo[2,3-b]pyridin-3-amine(9CI)
1H-Pyrrolo[2,3-b]pyridin-3-ylaMine3-AMino-7-azaindole
3-Amino-7-azaindole (1H-Pyrrolo[2,3-b]pyridin-3-amine)

MDL Number

MFCD08272227

Customs Code

2933990090

FAQ

What are the physical and chemical properties of 1H-Pyrrolo[2,3-b]pyridin-3-amine (CAS: 189882-31-3)?

1H-Pyrrolo[2,3-b]pyridin-3-amine is a solid with a crystalline form. Its molecular weight is approximately 163.19 g/mol. It has a low solubility in water but is soluble in common organic solvents such as methanol and dimethylformamide. This compound is moderately reactive, particularly towards nucleophilic substitution reactions. It is stable under normal conditions but should be stored in a dry environment to prevent hydrolysis.

How is 1H-Pyrrolo[2,3-b]pyridin-3-amine (CAS: 189882-31-3) typically synthesized?

1H-Pyrrolo[2,3-b]pyridin-3-amine can be synthesized via the reaction of 3-formylpyrrolo[2,3-b]pyridine with ammonia under basic conditions. The reaction typically involves refluxing the mixture in an aqueous ammonia solution. The yield is around 75-80%, and the product is isolated by recrystallization from a suitable solvent.

What industries use 1H-Pyrrolo[2,3-b]pyridin-3-amine (CAS: 189882-31-3)?

1H-Pyrrolo[2,3-b]pyridin-3-amine finds applications in various industries. It is used in the pharmaceutical industry as an intermediate for drug synthesis. In materials science, it is employed in the development of conductive polymers and organic semiconductors. Additionally, it is utilized in the fabrication of chemical sensors due to its unique electronic properties.

What precautions should be taken when handling 1H-Pyrrolo[2,3-b]pyridin-3-amine (CAS: 189882-31-3)?

When handling 1H-Pyrrolo[2,3-b]pyridin-3-amine, it is important to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and lab coats. This material should be handled in a well-ventilated area or a laboratory fume hood to minimize inhalation risk. In case of spillage, ensure proper disposal according to safety data sheet (SDS) guidelines. Always refer to the SDS for detailed safety information and emergency procedures.