2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone hydrochloride (1:1) | CAS No. 1867-66-9

2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone hydrochloride (1:1)

Basic Information

CAS Number

1867-66-9

Molecular Formula

C13H17Cl2NO

Molecular Weight

274.19 g/mol

AD

Basic Physical Properties

Melting Point

252-254°C

Flash Point

9℃

Solubility

H2O: 200 mg/mL

CNC1(CCCCC1=O)C2=CC=CC=C2Cl.Cl

InChI

InChI=1S/C13H16ClNO.ClH/c1-15-13(9-5-4-8-12(13)16)10-6-2-3-7-11(10)14;/h2-3,6-7,15H,4-5,8-9H2,1H3;1H

InChIKey

VCMGMSHEPQENPE-UHFFFAOYSA-N

LogP

3.3196000000000025

pKa

7.5(at 25℃)

Topological Polar Surface Area

29.1 Ų

Hydrogen Bond Donor/Acceptor

1 / 2

Complexity

269

Safety Information

View Safety Information

Hazard Class

Class 6.1(b) Class 6.1(b)

Toxicity

LD50 in adult mice, rats (mg/kg): 224 ±4, 229 ±5 i.p. (Goldenthal)

Synonyms & References

English

  • Ketamine-d4 Hydrochloride
  • Ketamine Hydrochloride Injection, USP
  • Zetamine
  • CYCLOHEXANONE, 2-(2-CHLOROPHENYL)-2-(METHYLAMINO)-, HYDROCHLORIDE (1:1)
  • CI-581
  • CHEBI:650657
  • Ketamini hydrochloridum
  • NSC116131
  • KETAMINE HYDROCHLORIDE [USP MONOGRAPH]
  • AKOS005287313
  • KETAMINE HYDROCHLORIDE [EP MONOGRAPH]
  • Ketolar
  • DEA No. 7285
  • Ketamine.HCl
  • EC 217-484-6
  • KETAMINE HYDROCHLORIDE [GREEN BOOK]
  • KETAMINE (+-)-2-(o-chlorophenyl)-2-(methylamino)cyclohexanonehydrochloride
  • CYCLOHEXANONE, 2-(O-CHLOROPHENYL)-2-(METHYLAMINO)-, HYDROCHLORIDE, (+/-)-
  • Ketanest
  • DTXCID2020137
  • Ketaset
  • Calipsol
  • A813079
  • Ketavet 100
  • DTXSID4040137
  • Ketalar
  • KETAMINE HYDROCHLORIDE (EP IMPURITY)
  • CL-369
  • NSC-116131
  • C07843
  • Ketamine hydrochloride [USAN:USP:JAN]

Customs Code

2921499090

FAQ

What are the physical and chemical properties of 2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone hydrochloride (CAS: 1867-66-9)?

2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone hydrochloride (CAS: 1867-66-9) is a crystalline solid with a molecular weight of approximately 261.7 g/mol. It has a solubility of about 0.5 g/100 mL in water. This compound exhibits moderate reactivity in the presence of bases. It is stable under normal storage conditions but should be kept away from strong acids and oxidizers.

How is 2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone hydrochloride (CAS: 1867-66-9) typically synthesized?

2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone hydrochloride (CAS: 1867-66-9) is commonly synthesized via the reaction of 2-(2-chlorophenyl)-2-(methylamino)cyclohexanone with hydrochloric acid. The process involves careful control of pH and temperature to achieve a high yield of the desired product.

What industries use 2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone hydrochloride (CAS: 1867-66-9)?

2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone hydrochloride (CAS: 1867-66-9) is used in various industries, including pharmaceuticals for intermediate synthesis, and in the development of new materials such as polymers and sensors. Its use in semiconductors is also reported, although its specific application there is less common.

What precautions should be taken when handling 2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone hydrochloride (CAS: 1867-66-9)?

When handling 2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone hydrochloride (CAS: 1867-66-9), it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or fume hood due to its volatility. Spills should be addressed immediately with appropriate cleanup procedures, and the Material Safety Data Sheet (MSDS) should be consulted for detailed information on safe handling and disposal.

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