N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-4-quinazolinamine

Basic Information

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CAS Number

184475-35-2

Molecular Formula

C22H24ClFN4O3

Molecular Weight

446.91 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Physical State

Powder

Melting Point

194.0 to 198.0 deg-C

Boiling Point

586.8°C at 760 mmHg

Density

1.322

Flash Point

308.7℃

Solubility

Sparingly soluble (<pH4)

Refractive Index

1.621

SMILES

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COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN4CCOCC4

InChI

InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27)

InChIKey

XGALLCVXEZPNRQ-UHFFFAOYSA-N

LogP

4.275600000000003

Topological Polar Surface Area

68.74000000000001 Å²

Hydrogen Bond Donor/Acceptor

1 / 7

Complexity

545

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H351 Suspected of causing cancer
Carcinogenicity

H361 Suspected of damaging fertility or the unborn child
Reproductive toxicity

H373 Causes damage to organs through prolonged or repeated exposure
Specific target organ toxicity, repeated exposure

Synonyms & References

English

N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-amine
GEFITINIB
AKOS 91371
n-(3-chloro-4-fluoro-phenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine
N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-4-quinazolinamine
ZD 1839
4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-
Gefitinib(TINIBS)
Gefitinib (ZD1839)
Gefitinib (ZD1839, Iressa®)
Iressa
N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine
&nbsp
Irressat
ZD-1839
Gefinitib
Getfitnib
Gifitinib
Ji Fei Ji
Gefitinib WS
ZD1839
Gefitinib, >=99%
Gefitinib iMpurity
N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(morpholin-4-yl)propoxy]quinazolin-4-amine
4-(3'-Chloro-4'-fluoroanilino)-7-methoxy-6-(3-morpholinopropoxy)quinazoline
N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholiny
N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4
N-(3-Chloro-4-fluoro-phenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine
Gefitinib
IRESSA
N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-amine

MDL Number

MFCD04307832

Customs Code

29143900

FAQ

What is N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-4-quinazolinamine (CAS: 184475-35-2)?

N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-4-quinazolinamine (CAS: 184475-35-2) is a synthetic organic compound with a complex chemical structure featuring a quinazolinamine core. It contains functional groups such as methoxy, chloro, fluoro, and morpholine, making it a potential pharmaceutical intermediate. The compound is known for its solubility in organic solvents and is often utilized in drug development research for its biological activity.

What are the main uses of N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-4-quinazolinamine (CAS: 184475-35-2)?

This compound is primarily used in pharmaceutical research as a key intermediate in the synthesis of drug molecules targeting cancer and neurological disorders. Its unique structure allows for modifications to enhance therapeutic efficacy. Additionally, it may find applications in chemical synthesis and as a research tool for studying molecular interactions, though specific industrial or food uses are not widely documented.

Is N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-4-quinazolinamine (CAS: 184475-35-2) safe?

Safety of N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-4-quinazolinamine (CAS: 184475-35-2) depends on exposure conditions. It is generally considered hazardous due to potential toxicity, requiring proper handling with personal protective equipment (PPE). Safety standards emphasize avoiding inhalation, skin contact, and ingestion, and it should be stored in a controlled environment to minimize risks during research or industrial use.

How should N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-4-quinazolinamine (CAS: 184475-35-2) be stored?

N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-4-quinazolinamine (CAS: 184475-35-2) should be stored in a cool, dry place (2-8°C), protected from light. It requires airtight containers to maintain stability and prevent moisture absorption. Avoid exposure to heat or humidity, and ensure storage in a well-ventilated area to preserve its chemical integrity and safety profile.