AMYLOID BETA-PROTEIN (6-20)

Basic Information

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CAS Number

183745-82-6

Molecular Formula

C88H120F3N23O25

Molecular Weight

1957.03 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

SMILES

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FC(C(=O)O)(F)F.O=C([C@H](CC(C)C)NC([C@H](CCCCN)NC([C@H](CCC(N)=O)NC([C@H](CC1=CNC=N1)NC([C@H](CC1=CNC=N1)NC([C@H](C(C)C)NC([C@H](CCC(=O)O)NC([C@H](CC1C=CC(=CC=1)O)NC(CNC([C@H](CO)NC([C@H](CC(=O)O)NC([C@H](CC1=CNC=N1)N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)N[C@H](C(N[C@H](C(N[C@H](C(=O)O)CC1C=CC=CC=1)=O)CC1C=CC=CC=1)=O)C(C)C

InChI

1S/C86H119N23O23.C2HF3O2/c1-45(2)29-59(83(128)109-72(47(5)6)84(129)104-61(30-48-15-9-7-10-16-48)79(124)106-65(86(131)132)32-49-17-11-8-12-18-49)102-75(120)56(19-13-14-28-87)98-76(121)57(24-26-67(89)112)99-80(125)62(34-52-38-91-43-95-52)103-81(126)63(35-53-39-92-44-96-53)105-85(130)71(46(3)4)108-77(122)58(25-27-69(114)115)100-78(123)60(31-50-20-22-54(111)23-21-50)97-68(113)40-93-74(119)66(41-110)107-82(127)64(36-70(116)117)101-73(118)55(88)33-51-37-90-42-94-51;3-2(4,5)1(6)7/h7-12,15-18,20-23,37-39,42-47,55-66,71-72,110-111H,13-14,19,24-36,40-41,87-88H2,1-6H3,(H2,89,112)(H,90,94)(H,91,95)(H,92,96)(H,93,119)(H,97,113)(H,98,121)(H,99,125)(H,100,123)(H,101,118)(H,102,120)(H,103,126)(H,104,129)(H,105,130)(H,106,124)(H,107,127)(H,108,122)(H,109,128)(H,114,115)(H,116,117)(H,131,132);(H,6,7)/t55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,71-,72-;/m0./s1

InChIKey

VDOWMFRXBPFSNE-FEDQHUJESA-N

LogP

-4.134299999999987

Topological Polar Surface Area

778.2300000000005 Å²

Hydrogen Bond Donor/Acceptor

29 / 48

Complexity

3910

Synonyms & References

English

L-Phenylalanine,L-histidyl-L-a-aspartyl-L-serylglycyl-L-tyrosyl-L-a-glutamyl-L-valyl-L-histidyl-L-histidyl-L-glutaminyl-L-lysyl-L-leucyl-L-valyl-L-phenylalanyl-(9CI)
H-HIS-ASP-SER-GLY-TYR-GLU-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-OH
Amyloid β -Protein (6-20)
L-Phenylalanine,L-histidyl-L-a-aspartyl-L-serylglycyl-L-tyrosyl-L-a-glutamyl-L-valyl-L-histidy...
L-Phenylalanine,L-histidyl-L-a-aspartyl-L-serylglycyl-L-tyrosyl-L-a-glutamyl-L-valyl-L-histidyl-L-histidyl-L-glutaminyl-L-lys
AMyloid b-Protein (6-20)
AMYLOID BETA-PROTEIN (6-20)
Amyloid beta-Protein (6-20), human
CID 145707742

MDL Number

MFCD08702743

FAQ

What are the physical and chemical properties of AMYLOID BETA-PROTEIN (6-20) (CAS: 183745-82-6)?

AMYLOID BETA-PROTEIN (6-20) (CAS: 183745-82-6) is a peptide with a molecular weight of approximately 231 Da. It is poorly soluble in water but soluble in organic solvents like DMSO. The compound is known for its aggregation properties, which make it relevant in the study of neurodegenerative diseases. It is reactive towards proteases and can form amyloid fibrils under specific conditions.

How is AMYLOID BETA-PROTEIN (6-20) (CAS: 183745-82-6) typically synthesized?

AMYLOID BETA-PROTEIN (6-20) (CAS: 183745-82-6) can be synthesized via solid-phase or solution-phase peptide synthesis. Common methods include using Fmoc chemistry or Boc protection strategies. The synthesis typically involves coupling steps with high yields and selectivity, followed by cleavage from the resin or solid support using strong base like piperidine or trifluoroacetic acid.

What industries use AMYLOID BETA-PROTEIN (6-20) (CAS: 183745-82-6)?

AMYLOID BETA-PROTEIN (6-20) (CAS: 183745-82-6) is primarily used in the pharmaceutical industry for the development of diagnostic tools and therapeutic strategies against Alzheimer's disease. It also finds applications in research related to protein aggregation and amyloid formation, which are of interest in both academic and industrial settings.

What precautions should be taken when handling AMYLOID BETA-PROTEIN (6-20) (CAS: 183745-82-6)?

When handling AMYLOID BETA-PROTEIN (6-20) (CAS: 183745-82-6), it is important to use personal protective equipment (PPE) such as gloves and safety goggles. Work should be conducted in a fume hood to minimize inhalation risks. Spills should be cleaned up with appropriate absorbent materials, and the area should be ventilated. Always consult the Safety Data Sheet (SDS) for detailed information on safe handling and disposal.