AMYLOID BETA-PROTEIN (6-20)(CAS: 183745-82-6)

AMYLOID BETA-PROTEIN (6-20) (CAS: 183745-82-6) is a peptide with a molecular weight of approximately 231 Da. It is poorly soluble in water but soluble in organic solvents like DMSO. The compound is known for its aggregation properties, which make it relevant in the study of neurodegenerative diseases. It is reactive towards proteases and can form amyloid fibrils under specific conditions.

AMYLOID BETA-PROTEIN (6-20) (CAS: 183745-82-6) can be synthesized via solid-phase or solution-phase peptide synthesis. Common methods include using Fmoc chemistry or Boc protection strategies. The synthesis typically involves coupling steps with high yields and selectivity, followed by cleavage from the resin or solid support using strong base like piperidine or trifluoroacetic acid.

AMYLOID BETA-PROTEIN (6-20) (CAS: 183745-82-6) is primarily used in the pharmaceutical industry for the development of diagnostic tools and therapeutic strategies against Alzheimer's disease. It also finds applications in research related to protein aggregation and amyloid formation, which are of interest in both academic and industrial settings.

When handling AMYLOID BETA-PROTEIN (6-20) (CAS: 183745-82-6), it is important to use personal protective equipment (PPE) such as gloves and safety goggles. Work should be conducted in a fume hood to minimize inhalation risks. Spills should be cleaned up with appropriate absorbent materials, and the area should be ventilated. Always consult the Safety Data Sheet (SDS) for detailed information on safe handling and disposal.