N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride (1:1) | CAS No. 183319-69-9

N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride (1:1)

Basic Information

CAS Number

183319-69-9

Molecular Formula

C22H24ClN3O4

Molecular Weight

429.9 g/mol

AD

Basic Physical Properties

Physical State

Powder

Melting Point

228-235°C

Boiling Point

553.6°C at 760 mmHg

COCCOC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=CC(=C3)C#C)OCCOC.Cl

InChI

InChI=1S/C22H23N3O4.ClH/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22;/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25);1H

InChIKey

GTTBEUCJPZQMDZ-UHFFFAOYSA-N

LogP

4.28010

pKa

pKa (25°): 5.42

Complexity

525

Safety Information

View Safety Information

Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation
H319 Causes serious eye irritation
Serious eye damage/eye irritation
H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation
H412 Harmful to aquatic life with long lasting effects
Hazardous to the aquatic environment, long-term hazard

Synonyms & References

English

  • ERLOTINIB HYDROCHLORIDE [MART.]
  • AKOS015849087
  • BCPP000238
  • DA87705X9K
  • N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-quinazolin-4-amine hydrochloride
  • 4-Quinazolinamine, N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-, monohydrochloride
  • erlotinib, hydrochloride salt
  • NS00076170
  • Erlotinib HCl (OSI-744)
  • N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine;hydrochloride
  • erlotinib HCl
  • Tarceva (Erlotinib Hydrochloride)
  • N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine, monohydrochloride
  • Tarceva (OSI)
  • OSI-744
  • [6,7-Bis(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl- phenyl)amine hydrochloride
  • ERLOTINIB HYDROCHLORIDE [USP-RS]
  • 183319-69-9 pound not183321-74-6
  • BCP9000658
  • ERLOTINIB HYDROCHLORIDE [WHO-DD]
  • MFCD07781272
  • SMR002529980
  • BP-30224
  • ERLOTINIB HYDROCHLORIDE [ORANGE BOOK]
  • Ro-50-8231
  • PB30965
  • CP-358774-01
  • KS-1202
  • 183319-69-9 (HCl)
  • BE164421
  • SB16917

MDL Number

MFCD07781272

Customs Code

2933990090

FAQ

What is N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride (1:1) (CAS: 183319-69-9)?

N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride (1:1), with CAS number 183319-69-9, is a quinazolinamine derivative commonly used in pharmaceutical research. It features a 3-ethynylphenyl group and two methoxyethoxy substituents, making it a potential compound for drug development. The hydrochloride salt form enhances its solubility and stability in aqueous environments.

What are the main uses of N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride (1:1) (CAS: 183319-69-9)?

This compound is primarily used in pharmaceutical research for its potential as a therapeutic agent. It may serve as an intermediate or active pharmaceutical ingredient in the development of drugs targeting neurological or oncological conditions. Its chemical structure suggests applications in medicinal chemistry, particularly in the design of compounds with specific biological activity.

Is N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride (1:1) (CAS: 183319-69-9) safe?

N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride (1:1) is generally considered safe when handled properly. However, as a chemical compound, it should be treated with caution, and appropriate safety measures such as gloves and ventilation should be used. Safety data sheets (SDS) should be consulted for detailed handling and exposure guidelines.

How should N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride (1:1) (CAS: 183319-69-9) be stored?

This compound should be stored in a cool, dry, and dark place, ideally at temperatures below 25°C. It is sensitive to moisture and light, so it should be kept in airtight containers. Storage in a well-ventilated area is recommended to prevent exposure to air and maintain stability over time.

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