1-(Trimethylsilyl)-1H-imidazole

Basic Information

View in Editor

CAS Number

18156-74-6

Molecular Formula

C6H12N2Si

Molecular Weight

140.26 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Melting Point

-42 ºC

Boiling Point

93-94 °C/14 mmHg

Refractive Index

n20/D 1.475(lit.)

Vapor Pressure

0.2±0.4 mmHg at 25°C

SMILES

View in Editor

C[Si](C)(C)N1C=CN=C1

InChI

InChI=1S/C6H12N2Si/c1-9(2,3)8-5-4-7-6-8/h4-6H,1-3H3

InChIKey

YKFRUJSEPGHZFJ-UHFFFAOYSA-N

LogP

1.5660999999999998

Topological Polar Surface Area

17.82 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Complexity

97.7

Safety Information

View Safety Information

Hazard Statement

H225 Highly Flammable liquid and vapor
Flammable liquids

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class 3 Class 3

Sensitiveness

Moisture Sensitive

Synonyms & References

English

DTXSID5066326
SMR000568407
AKOS005216567
J-523191
1-trimethylsilylimidazole
MLS001074885
1-(Trimethylsily)imidazole
EINECS 242-040-3
1-Imidazolyltrimethylsilane
Q27158312
T0693
1-(Trimethylsilyl)-1H-imidazole
N-trimethylsilyl-imidazol
A812623
J-802246
IMIDAZOLE, N-(TRIMETHYLSILYL)-
1-(Trimethylsilyl)imidazole
EN300-247308
Tms-Imidazole (=N-Trimethylsilylimidazole) [For Gas Chromatography]
trimethylsilylimidazole
N-Trimethylsilylimidazole [Trimethylsilylating Reagent]
EC 242-040-3
imidazol-1-yl-trimethyl-silane
CHEBI:85063
1-(trimethylsilyl)-imidazole
N-Trimethylsilylimidazole
HMS2231B11
T0585
N-(Trimethylsilyl)imidazole
Imidazole, 1-(trimethylsilyl)-
n-trimethylsilyl imidazole

MDL Number

MFCD00005280

Customs Code

29332990

FAQ

What is 1-(Trimethylsilyl)-1H-imidazole (CAS: 18156-74-6)?

1-(Trimethylsilyl)-1H-imidazole is an organic compound with the chemical formula C8H17N2Si. It is a silylated derivative of imidazole, known for its stability and low reactivity. This compound is commonly used as a protecting group in organic synthesis and is characterized by its ability to donate a silyl group to functionalized molecules, enhancing their synthetic utility.

What are the main uses of 1-(Trimethylsilyl)-1H-imidazole (CAS: 18156-74-6)?

1-(Trimethylsilyl)-1H-imidazole is widely used in pharmaceutical research, organic synthesis, and materials science. It serves as a protecting group for imidazole functionalities, facilitating selective reactions. Additionally, it is applied in the development of drug molecules and as a catalyst in various chemical processes due to its unique chemical properties.

Is 1-(Trimethylsilyl)-1H-imidazole (CAS: 18156-74-6) safe?

1-(Trimethylsilyl)-1H-imidazole is generally considered safe when handled properly. It has low toxicity and is not classified as a hazardous substance under standard safety guidelines. However, standard laboratory safety practices should be followed, including the use of gloves and proper ventilation, to minimize exposure and ensure safe handling.

How should 1-(Trimethylsilyl)-1H-imidazole (CAS: 18156-74-6) be stored?

1-(Trimethylsilyl)-1H-imidazole should be stored in a cool, dry place away from moisture and light. It is stable under normal storage conditions and should be kept in a sealed container. Proper storage helps maintain its chemical integrity and prolongs shelf life, making it suitable for both laboratory and industrial applications.