5-Fluoro-1-(tetrahydro-2-furanyl)-2,4(1H,3H)-pyrimidinedione

Basic Information

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CAS Number

17902-23-7

Molecular Formula

C8H9FN2O3

Molecular Weight

200.17 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Physical State

Powder

Melting Point

167.0 to 171.0 deg-C

Boiling Point

oCat760mmHg

Flash Point

Solubility

DMSO: >50mg/mL

Refractive Index

1.557

SMILES

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C1CC(OC1)N2C=C(C(=O)NC2=O)F

InChI

InChI=1S/C8H9FN2O3/c9-5-4-11(6-2-1-3-14-6)8(13)10-7(5)12/h4,6H,1-3H2,(H,10,12,13)

InChIKey

WFWLQNSHRPWKFK-UHFFFAOYSA-N

LogP

-0.015300000000000036

Topological Polar Surface Area

64.09 Å²

Hydrogen Bond Donor/Acceptor

1 / 5

Complexity

316

Safety Information

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Hazard Statement

H300 Fatal if swallowed
Acute toxicity, oral

H373 Causes damage to organs through prolonged or repeated exposure
Specific target organ toxicity, repeated exposure

Hazard Class

Class 6.1 Class 6.1

Toxicity

LD50 in mice (mg/kg): 900 orally (3 days) (Yasumoto); 750 i.p. (FR 1574684), also reported as 1150 i.p. (Smart)

Synonyms & References

English

Fulfeel
2,4(1H,3H)-Pyrimidinedione, 5-fluoro-1-(tetrahydro-2-furanyl)-, didehydroderiv.
F-5-FU
HMS2232E05
FT-0654170
FT-0693965
HMS2090K04
MLS001424119
HMS3654P13
HMS3393B15
Florafur
Phthorafur [Czech]
1-(2-Tetrahydrofuryl)-5-fluorouracil
Tegafur, >=98% (HPLC), powder
TEGAFUR [EMA EPAR]
URACIL, 5-FLUORO-1-(TETRAHYDRO-2-FURYL)-
TEGAFUR [WHO-DD]
Furofutran
FT-0653732
HMS2051B15
17902-23-7
Coparogin
Citofur
1548R74NSZ
FT207
CHEBI:32188
UPCMLD-DP063
Franroze
Tefsiel C
Sunfural
Furflucil

MDL Number

MFCD00012351

Customs Code

2942000000

FAQ

What is 5-Fluoro-1-(tetrahydro-2-furanyl)-2,4(1H,3H)-pyrimidinedione (CAS: 17902-23-7)?

5-Fluoro-1-(tetrahydro-2-furanyl)-2,4(1H,3H)-pyrimidinedione (CAS: 17902-23-7) is a heterocyclic compound containing a pyrimidinedione core with a fluorine substituent at the 5-position and a tetrahydrofuran ring attached to the 1-position. Its chemical structure features two ketone groups and a furan ring, making it a key intermediate in pharmaceutical research. It is typically a white solid with moderate solubility in polar solvents.

What are the main uses of 5-Fluoro-1-(tetrahydro-2-furanyl)-2,4(1H,3H)-pyrimidinedione (CAS: 17902-23-7)?

5-Fluoro-1-(tetrahydro-2-furanyl)-2,4(1H,3H)-pyrimidinedione (CAS: 17902-23-7) is primarily used in pharmaceutical development for synthesizing antifungal and antiviral agents. It also serves as a research compound in organic chemistry for studying reaction mechanisms. Industrial applications include its use as a precursor in agrochemical and material science processes.

Is 5-Fluoro-1-(tetrahydro-2-furanyl)-2,4(1H,3H)-pyrimidinedione (CAS: 17902-23-7) safe?

5-Fluoro-1-(tetrahydro-2-furanyl)-2,4(1H,3H)-pyrimidinedione (CAS: 17902-23-7) is generally considered safe when handled properly. It may cause mild skin or eye irritation, so protective gear like gloves and goggles is recommended. Safety standards emphasize adherence to chemical exposure guidelines and proper disposal to ensure minimal environmental impact.

How should 5-Fluoro-1-(tetrahydro-2-furanyl)-2,4(1H,3H)-pyrimidinedione (CAS: 17902-23-7) be stored?

5-Fluoro-1-(tetrahydro-2-furanyl)-2,4(1H,3H)-pyrimidinedione (CAS: 17902-23-7) should be stored in a cool, dry place away from light. Maintain temperature between 2-8°C and ensure low humidity levels. Keep in airtight, inert containers to prevent degradation. Avoid exposure to moisture and incompatible substances to ensure stability.