Ambrisentan Impurity 9

Basic Information

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CAS Number

178306-51-9

Molecular Formula

C16H16O4

Molecular Weight

272.3 g/mol

Basic Physical Properties

Melting Point

112-116°C

Boiling Point

430 ºC

Flash Point

158 ºC

SMILES

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COC(C1=CC=CC=C1)(C2=CC=CC=C2)C(C(=O)O)O

InChI

InChI=1S/C16H16O4/c1-20-16(14(17)15(18)19,12-8-4-2-5-9-12)13-10-6-3-7-11-13/h2-11,14,17H,1H3,(H,18,19)

InChIKey

RQJWOLFMWKZKCJ-UHFFFAOYSA-N

LogP

2.0220999999999996

Topological Polar Surface Area

66.76 Å²

Hydrogen Bond Donor/Acceptor

2 / 4

Complexity

298

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

2-Hydroxy-3-methoxy-3,3-diphenylpropanoic acid
2-Hydroxy-3-methyoxy-3,3-diphenylpropanoic acid
2-hydroxy-3-methoxy-3,3-diphenyl propionic acid
3-methoxy-2-hydroxy-3,3-diphenylpropionic acid
FD7217
hydroxymethoxydiphenylpropanoicacid
rac-2-hydroxy-3-methoxy-3,3-diphenylpropionic acid
alpha-Hydroxy-beta-methoxy-beta-phenylbenzenepropanoic acid
Ambrisentan PI-2
2-Hydroxy-3-methoxy-3,3-diphenylpropionic acid
2-hydroxy-3-methoxy-3,3-diphenyl-propanoic Acid
RQJWOLFMWKZKCJ-UHFFFAOYSA-N
BCP04675
EBD274371
CH0084
TRA0169747
RP15191
SY102636
AB0035928
AX8163208
ST24028033
2-hydroxy-3-methoxy-3,3-diphenylpropanoic acid

MDL Number

MFCD13152279

Customs Code

2918990090

FAQ

What regulatory guidelines apply to Ambrisentan Impurity 9 (CAS: 178306-51-9)?

Ambrisentan Impurity 9 (CAS: 178306-51-9) must comply with regulatory guidelines such as GHS (Global Harmonized System of Classification and Labeling of Chemicals) for hazard communication. In the European Union, REACH (Registration, Evaluation, Authorisation and Restriction of Chemicals) regulations apply. Additionally, FDA and EPA regulations govern its use and disposal in the United States.

Are there alternatives to Ambrisentan Impurity 9 (CAS: 178306-51-9) in synthesis?

While Ambrisentan Impurity 9 (CAS: 178306-51-9) is a critical component in the synthesis of Ambrisentan, alternatives such as isomeric forms or analogs can be used. Common alternative reagents include similar functionalized amides or related compounds that can serve as precursors in the synthesis process.

What is the market or research trend for Ambrisentan Impurity 9 (CAS: 178306-51-9)?

The market for Ambrisentan Impurity 9 (CAS: 178306-51-9) is closely tied to the broader market for Ambrisentan, a pulmonary arterial hypertension treatment. Research trends focus on optimizing synthesis methods and improving purity to enhance drug efficacy. Market demand is driven by ongoing clinical research and the need for high-quality intermediates in pharmaceuticals.

How should waste containing Ambrisentan Impurity 9 (CAS: 178306-51-9) be handled?

Waste containing Ambrisentan Impurity 9 (CAS: 178306-51-9) should be collected in appropriate containers and disposed of by a professional waste disposal service. Incineration or chemical treatment may be necessary to ensure complete destruction of the impurity. Strict environmental protection precautions must be followed to prevent contamination and ensure compliance with local and international regulations.