4,5-Dihydro-1,3-thiazol-2-amine

Basic Information

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CAS Number

1779-81-3

Molecular Formula

C3H6N2S

Molecular Weight

102.16 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Melting Point

79-82 ºC

Boiling Point

221.8℃ at 760 mmHg

Water Solubility

Soluble in water.

Refractive Index

1.5500 (estimate)

SMILES

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C1CSC(=N1)N

InChI

InChI=1S/C3H6N2S/c4-3-5-1-2-6-3/h1-2H2,(H2,4,5)

InChIKey

REGFWZVTTFGQOJ-UHFFFAOYSA-N

LogP

0.04790000000000011

Topological Polar Surface Area

38.379999999999995 Å²

Hydrogen Bond Donor/Acceptor

2 / 2

Complexity

78.9

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

4,5-dihydrothiazol-2-amine
FT-0611022
EN300-33927
2-Iminothiazolidine
NSC 24626
2-Thiazolin-2-ylamine
DTXSID4061961
2-Thiazoline, 2-amino-
InChI=1/C3H6N2S/c4-3-5-1-2-6-3/h1-2H2,(H2,4,5
AKOS003269613
2-amino-thiazoline
4,5-Dihydro-1,3-thiazol-2-amine
2-Aminothiazoline
NSC3110
2-Aminothiazoline (VAN)
CAMFAZOLINUM
SY017228
UNII-5JC2YZG56Q
4,5-dihydro-thiazol-2-yl-amine
WLN: T5N CS AUTJ BZ
H11788
DB02335
SCHEMBL354824
4,5-dihydro-thiazol-2-ylamine
2-Amino-2-thiazoline
USAF PD-57
2-amino-Delta(2)-thiazoline
EINECS 217-224-1
AKOS003268141
4,5-Dihydro-1,3-thiazol-2-amine #
AMY202003298

MDL Number

MFCD00005313

Customs Code

29341000

FAQ

What are the physical and chemical properties of 4,5-Dihydro-1,3-thiazol-2-amine (CAS: 1779-81-3)?

4,5-Dihydro-1,3-thiazol-2-amine (CAS: 1779-81-3) is a colorless to white crystalline solid with a molecular weight of approximately 145.17 g/mol. It is slightly soluble in water and has poor solubility in organic solvents. This amine is relatively stable but can react with strong acids to form thiazolium salts. It is used in various applications due to its chemical reactivity and stability in aqueous environments.

How is 4,5-Dihydro-1,3-thiazol-2-amine (CAS: 1779-81-3) typically synthesized?

4,5-Dihydro-1,3-thiazol-2-amine (CAS: 1779-81-3) can be synthesized through a multi-step process starting from thiazole. Common methods include the reaction of thiazole with hydrazine hydrate followed by hydrolysis. This process yields the desired amine with good selectivity and moderate to high yield, making it a reliable method for industrial production.

What industries use 4,5-Dihydro-1,3-thiazol-2-amine (CAS: 1779-81-3)?

4,5-Dihydro-1,3-thiazol-2-amine (CAS: 1779-81-3) is used in various industries, including pharmaceuticals, where it serves as a precursor for drug synthesis. It is also utilized in the polymer industry for stabilizing polymers and in the sensor industry for its electronic properties. Additionally, it finds applications in semiconductor technology for its unique reactivity and stability.

What precautions should be taken when handling 4,5-Dihydro-1,3-thiazol-2-amine (CAS: 1779-81-3)?

Proper safety measures should be taken when handling 4,5-Dihydro-1,3-thiazol-2-amine (CAS: 1779-81-3). Wear appropriate personal protective equipment (PPE) including gloves and safety goggles. Store the compound in a sealed container in a cool, dry place away from sources of heat and ignition. In case of spillage, contain the material and clean up using appropriate methods. Always consult the Safety Data Sheet (SDS) for detailed handling instructions and emergency procedures.