Ethyl 2-amino-1,3-oxazole-4-carboxylate

Basic Information

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CAS Number

177760-52-0

Molecular Formula

C6H8N2O3

Molecular Weight

156.14 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Melting Point

135-140 °C

Boiling Point

269.1°C at 760 mmHg

Density

1.278

Flash Point

124.9oC

Refractive Index

1.523

SMILES

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CCOC(=O)C1=COC(=N1)N

InChI

InChI=1S/C6H8N2O3/c1-2-10-5(9)4-3-11-6(7)8-4/h3H,2H2,1H3,(H2,7,8)

InChIKey

NBABLVASYFPOEV-UHFFFAOYSA-N

LogP

0.4335000000000001

Topological Polar Surface Area

78.35 Å²

Hydrogen Bond Donor/Acceptor

2 / 5

Complexity

151

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

4-OXAZOLECARBOXYLIC ACID, 2-AMINO-, ETHYL ESTER
Ethyl 2-aminooxazole-4-carboxylate
Z1201623660
CS-W016240
SCHEMBL479860
PS-3653
AM20090052
NSC-263857
NBABLVASYFPOEV-UHFFFAOYSA-N
SCHEMBL23727298
177760-52-0
ethyl-2-amino-4-oxazole carboxylate
CS-10483
Ethyl2-aminooxazole-4-carboxylate
2-amino-oxazole-4-carboxylic acid ethyl ester
ETHYL-2-AMINOOXAZOLE-4-CARBOXYLATE
DTXSID00312892
SY019431
NSC263857
A3941
F2145-0713
2-Aminooxazole-4-carboxylic acid ethyl ester
AKOS005255719
FT-0601646
2-AMINO-4-OXAZOLECARBOXYLIC ACID ETHYL ESTER
ethyl 2-amino-1,3-oxazole-4-carboxylate
AC-25572
BCP22452
MFCD06659907
PB12381
2-aminooxazol-4-carboxylic acid ethylester

MDL Number

MFCD06659907

Customs Code

2934999090

FAQ

What are the physical and chemical properties of Ethyl 2-amino-1,3-oxazole-4-carboxylate (CAS: 177760-52-0)?

Ethyl 2-amino-1,3-oxazole-4-carboxylate (CAS: 177760-52-0) is a white crystalline solid with a molecular weight of approximately 194.25 g/mol. It is slightly soluble in water and more soluble in organic solvents like dichloromethane and ethanol. This compound exhibits good reactivity towards nucleophiles and can undergo various chemical transformations. It has a pKa of around 4.5, indicating moderate acidity.

How is Ethyl 2-amino-1,3-oxazole-4-carboxylate (CAS: 177760-52-0) typically synthesized?

Ethyl 2-amino-1,3-oxazole-4-carboxylate (CAS: 177760-52-0) is typically synthesized via the condensation of ethyl 2-amino-1,3-oxazole-4-carboxylate with appropriate reagents. Common synthetic routes involve the use of sodium hydride and ethyl 2-amino-1,3-oxazole-4-carboxylate. The reaction is usually carried out in anhydrous organic solvents, and the yield can be up to 90% under optimized conditions.

What industries use Ethyl 2-amino-1,3-oxazole-4-carboxylate (CAS: 177760-52-0)?

Ethyl 2-amino-1,3-oxazole-4-carboxylate (CAS: 177760-52-0) has applications in the pharmaceutical industry, where it serves as a precursor for the synthesis of various bioactive compounds. It is also utilized in the polymer industry for the development of novel materials with improved properties. Additionally, it finds use in sensor technology and semiconductor manufacturing due to its unique chemical properties and reactivity.

What precautions should be taken when handling Ethyl 2-amino-1,3-oxazole-4-carboxylate (CAS: 177760-52-0)?

When handling Ethyl 2-amino-1,3-oxazole-4-carboxylate (CAS: 177760-52-0), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up immediately using appropriate absorbents, and the area should be thoroughly rinsed. Safety data sheets (SDS) should be consulted for detailed handling and disposal instructions.